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    R08E3.3 CCDC22 N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    R08E3.3
    Official Full Name
    CCDC22 N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00019959
    Locus tag
    CELE_R08E3.3
    See related
    AllianceGenome:WB:WBGene00019959
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to be involved in positive regulation of ubiquitin-dependent protein catabolic process. Is expressed in anterior gonad arm. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 2. Orthologous to human CCDC22 (coiled-coil domain containing 22). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See R08E3.3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (4818593..4821715)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein Neighboring gene GATOR2 complex protein MIO zinc-ribbon like domain-containing protein Neighboring gene Adducin-related protein 1;Class II aldolase/adducin N-terminal domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein interaction mapping in C. elegans using proteins involved in vulval development. Walhout AJ, et al. Science, 2000 Jan 7. PMID 10615043
    2. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    3. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CCDC22 N-terminal domain-containing protein
    NP_001024848.1
    • Confirmed by transcript evidence
    NP_001024849.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4818593..4821715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029678.7 → NP_001024849.1  CCDC22 N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024849.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JP60
      Conserved Domains (3) summary
      pfam05667
      Location:1 → 420
      DUF812; Protein of unknown function (DUF812)
      pfam07889
      Location:284 → 350
      DUF1664; Protein of unknown function (DUF1664)
      pfam12010
      Location:259 → 297
      DUF3502; Domain of unknown function (DUF3502)

    2. NM_001029677.4 → NP_001024848.1  CCDC22 N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L007
      Conserved Domains (3) summary
      pfam05667
      Location:1 → 420
      DUF812; Protein of unknown function (DUF812)
      pfam07889
      Location:284 → 350
      DUF1664; Protein of unknown function (DUF1664)
      pfam12010
      Location:259 → 297
      DUF3502; Domain of unknown function (DUF3502)
    Nucleotide Protein
    Heading Accession and Version

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