znfx-1 NFX1-type zinc finger-containing protein 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: znfx-1
Official Full Name: NFX1-type zinc finger-containing protein 1 homolog
Primary source: WormBase:WBGene00014208
Locus tag: CELE_ZK1067.2
See related: AllianceGenome:WB:WBGene00014208
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated heterochromatin formation. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Is expressed in several structures, including Psub1; Psub2; Psub3; Psub4; and germ line. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human ZNFX1 (zinc finger NFX1-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See znfx-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 21

Sequence:: Chromosome: II; NC_003280.10 (9213702..9223150)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Caenorhabditis elegans TDRD5/7-like protein, LOTR-1, interacts with the helicase ZNFX-1 to balance epigenetic signals in the germline.
Title: The Caenorhabditis elegans TDRD5/7-like protein, LOTR-1, interacts with the helicase ZNFX-1 to balance epigenetic signals in the germline.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1067.2 (e-PCR)
- UniSTS:308246

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of nuclear RNA-directed RNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NFX1-type zinc finger-containing protein 1 homolog

NP_001367278.1

Confirmed by transcript evidence

NP_001379118.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9213702..9223150

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381556.1 → NP_001367278.1 NFX1-type zinc finger-containing protein 1 homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

E9P860, Q23388

Conserved Domains (6) summary

cd06008
Location:2017 → 2057

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

cd18808
Location:1536 → 1722

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd17936
Location:1434 → 1534

EEXXEc_NFX1; EEXXE-box helicase domain of NFX1

pfam13086
Location:1328 → 1499

AAA_11; AAA domain

NF033759
Location:1763 → 2130

exchanger_TraA; outer membrane exchange protein TraA

cl28899
Location:1040 → 1133

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
NM_001393146.1 → NP_001379118.1 NFX1-type zinc finger-containing protein 1 homolog [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (6) summary

cd06008
Location:1786 → 1826

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

cd18808
Location:1305 → 1491

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd17936
Location:1203 → 1303

EEXXEc_NFX1; EEXXE-box helicase domain of NFX1

pfam13086
Location:1097 → 1268

AAA_11; AAA domain

NF033759
Location:1532 → 1899

exchanger_TraA; outer membrane exchange protein TraA

cl28899
Location:809 → 902

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily