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    rod-1 Kinetochore-associated protein rod-1 [ Caenorhabditis elegans ]

    Gene ID: 177520, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rod-1
    Official Full Name
    Kinetochore-associated protein rod-1
    Primary source
    WormBase:WBGene00018900
    Locus tag
    CELE_F55G1.4
    See related
    AllianceGenome:WB:WBGene00018900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein domain specific binding activity. Involved in several processes, including chromosome organization; positive regulation of kinetochore assembly; and regulation of cell cycle process. Part of RZZ complex. Orthologous to human KNTC1 (kinetochore associated 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rod-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    16
    Sequence:
    Chromosome: IV; NC_003282.8 (7478452..7485327)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RING-CH-type domain-containing protein Neighboring gene SLC (SoLute Carrier) homolog Neighboring gene Putative pyrroline-5-carboxylate reductase Neighboring gene Histone H2A Neighboring gene putative histone H2B 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Disordered Spindly C-terminus Interacts with RZZ Subunits ROD-1 and ZWL-1 in the Kinetochore through the Same Sites in C. Elegans. Henen MA, et al. J Mol Biol, 2021 Feb 19. PMID 33450249, Free PMC Article
    2. Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment. Pereira C, et al. Curr Biol, 2018 Nov 5. PMID 30415699, Free PMC Article
    3. Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly. Gama JB, et al. J Cell Biol, 2017 Apr 3. PMID 28320824, Free PMC Article
    4. Microtubules oppose cortical actomyosin-driven membrane ingression during C. elegans meiosis I polar body extrusion. Quiogue AR, et al. PLoS Genet, 2023 Oct. PMID 37782660, Free PMC Article
    5. Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation. Cheerambathur DK, et al. Science, 2013 Dec 6. PMID 24231804, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of mitotic cell cycle spindle assembly checkpoint IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic chromosome movement towards spindle pole IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of kinetochore assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic sister chromatid separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic spindle pole body separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic spindle pole body separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to kinetochore IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to kinetochore involved in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to kinetochore involved in kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RZZ complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RZZ complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in kinetochore microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kinetochore-associated protein rod-1
    NP_501200.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7478452..7485327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068799.8 → NP_501200.1  Kinetochore-associated protein rod-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501200.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20849
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20849.1

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