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    hex-5 beta-N-acetylhexosaminidase [ Caenorhabditis elegans ]

    Gene ID: 181586, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hex-5
    Official Full Name
    beta-N-acetylhexosaminidase
    Primary source
    WormBase:WBGene00013497
    Locus tag
    CELE_Y70D2A.2
    See related
    AllianceGenome:WB:WBGene00013497
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables hexosaminidase activity. Involved in carbohydrate metabolic process. Is expressed in head muscle; tail; and vulva. Orthologous to human HEXD (hexosaminidase D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hex-5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (14901881..14905261, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sodium-dependent low-affinity dicarboxylate transporter 1 Neighboring gene Lipase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enzymatic properties and subtle differences in the substrate specificity of phylogenetically distinct invertebrate N-glycan processing hexosaminidases. Dragosits M, et al. Glycobiology, 2015 Apr. PMID 25488985, Free PMC Article
    2. N-glycan antennal modifications are altered in Caenorhabditis elegans lacking the HEX-4 N-acetylgalactosamine-specific hexosaminidase. Paschinger K, et al. J Biol Chem, 2023 Apr. PMID 36813232, Free PMC Article
    3. Biosynthesis of truncated N-linked oligosaccharides results from non-orthologous hexosaminidase-mediated mechanisms in nematodes, plants, and insects. Gutternigg M, et al. J Biol Chem, 2007 Sep 21. PMID 17636254, Free PMC Article
    4. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-N-acetylhexosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hexosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-N-acetylhexosaminidase
    NP_001366664.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14901881..14905261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381161.1 → NP_001366664.1  beta-N-acetylhexosaminidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7DY69, G5EEC8
      Conserved Domains (1) summary
      cd06565
      Location:25 → 340
      GH20_GcnA-like; Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine ...
    Nucleotide Protein
    Heading Accession and Version

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