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    • Showing Current items.

    inx-12 Innexin-12 [ Caenorhabditis elegans ]

    Gene ID: 171944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inx-12
    Official Full Name
    Innexin-12
    Primary source
    WormBase:WBGene00002134
    Locus tag
    CELE_ZK770.3
    See related
    AllianceGenome:WB:WBGene00002134
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable gap junction hemi-channel activity. Involved in positive regulation of nematode male tail tip morphogenesis. Predicted to be active in gap junction and plasma membrane. Is expressed in several structures, including epithelial cell; head ganglion; neurons; posterior lateral ganglion; and spermatid. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inx-12 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (3755488..3759039, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene MATH (meprin-associated Traf homology) domain containing Neighboring gene ncRNA Neighboring gene Innexin Neighboring gene Degenerin-like protein asic-1 Neighboring gene Uncharacterized protein Neighboring gene AMP-binding domain-containing protein;AMP-dependent synthetase/ligase domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca. Kovacevic I, et al. PLoS Genet, 2013 May. PMID 23671426, Free PMC Article
    2. Innexins get into the gap. Phelan P, et al. Bioessays, 2001 May. PMID 11340620
    3. The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. Barnes TM, et al. J Neurochem, 1997 Dec. PMID 9375655
    4. The role of gap junctions in Caenorhabditis elegans oocyte maturation and fertilization. Whitten SJ, et al. Dev Biol, 2007 Jan 15. PMID 16982048
    5. A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans. Nelson MD, et al. PLoS Genet, 2011 Mar. PMID 21408209, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables gap junction hemi-channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in gap junction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Innexin-12
    NP_491213.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3755488..3759039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058812.9 → NP_491213.1  Innexin-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491213.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01634
      Conserved Domains (1) summary
      pfam00876
      Location:18 → 377
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01634.1

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