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    gtl-2 LSDAT_euk domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178036, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gtl-2
    Official Full Name
    LSDAT_euk domain-containing protein
    Primary source
    WormBase:WBGene00001796
    Locus tag
    CELE_F54D1.5
    See related
    AllianceGenome:WB:WBGene00001796
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable monoatomic cation channel activity. Predicted to be involved in metal ion transport and monoatomic cation transmembrane transport. Located in basal plasma membrane. Is expressed in excretory cell; hypodermis; and pharynx. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; cataract; congenital stationary night blindness; and congenital stationary night blindness 1C. Orthologous to human TRPM1 (transient receptor potential cation channel subfamily M member 1); TRPM3 (transient receptor potential cation channel subfamily M member 3); and TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gtl-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    26
    Sequence:
    Chromosome: IV; NC_003282.8 (11273451..11281992)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Nuclear hormone receptor family member nhr-7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transient receptor potential melastatin (TRPM) channels mediate clozapine-induced phenotypes in Caenorhabditis elegans. Wang X, et al. J Neurogenet, 2014 Mar-Jun. PMID 24564792
    2. Novel Alleles of gon-2, a C. elegans Ortholog of Mammalian TRPM6 and TRPM7, Obtained by Genetic Reversion Screens. Lambie EJ, et al. PLoS One, 2015. PMID 26606136, Free PMC Article
    3. A Gαq-Ca²⁺ signaling pathway promotes actin-mediated epidermal wound closure in C. elegans. Xu S, et al. Curr Biol, 2011 Dec 6. PMID 22100061, Free PMC Article
    4. Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel. Teramoto T, et al. PLoS One, 2010 Mar 8. PMID 20221407, Free PMC Article
    5. A novel nondevelopmental role of the sax-7/L1CAM cell adhesion molecule in synaptic regulation in Caenorhabditis elegans. Opperman K, et al. Genetics, 2015 Feb. PMID 25488979, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study suggest that GTL-2 TRPM channel function in the excretory canal cell is important for clozapine's developmental effects.
      Title: Transient receptor potential melastatin (TRPM) channels mediate clozapine-induced phenotypes in Caenorhabditis elegans.
    2. Loss of gtl-2 function does not affect baseline synaptic transmission but can compensate for the excitation-inhibition imbalance caused by acr-2(gf).
      Title: TRPM channels modulate epileptic-like convulsions via systemic ion homeostasis.
    3. the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1
      Title: Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in metal ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LSDAT_euk domain-containing protein
    NP_502118.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11273451..11281992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069717.7 → NP_502118.4  LSDAT_euk domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502118.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20766
      Conserved Domains (1) summary
      pfam00520
      Location:918 → 1113
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version

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