U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ltah-1.1 Aminopeptidase ltah-1.1 [ Caenorhabditis elegans ]

    Gene ID: 178176, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ltah-1.1
    Official Full Name
    Aminopeptidase ltah-1.1
    Primary source
    WormBase:WBGene00016589
    Locus tag
    CELE_C42C1.11
    See related
    AllianceGenome:WB:WBGene00016589
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables aminopeptidase activity. Involved in peptide catabolic process. Located in cytosol. Orthologous to human LTA4H (leukotriene A4 hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ltah-1.1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (12279660..12281913)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mannose-1-phosphate guanylyltransferase catalytic subunit beta Neighboring gene Protein-lysine methyltransferase vkmt-1 Neighboring gene PAP2_C domain-containing protein Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Mitochondrial thiamine pyrophosphate carrier Neighboring gene Erlin

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The complement of family M1 aminopeptidases of Haemonchus contortus--Biotechnological implications. Mohandas N, et al. Biotechnol Adv, 2016 Mar-Apr. PMID 26597954
    2. Molecular cloning and functional expression of a Caenorhabditis elegans aminopeptidase structurally related to mammalian leukotriene A4 hydrolases. Baset HA, et al. J Biol Chem, 1998 Oct 23. PMID 9774412
    3. The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function. Liu Z, et al. PLoS Genet, 2022 Jan. PMID 35089916, Free PMC Article
    4. AP-1 Recruits SMAP-1/SMAPs to the trans-Golgi Network to Promote Sorting in Polarized Epithelia. Wang S, et al. Front Cell Dev Biol, 2021. PMID 34901019, Free PMC Article
    5. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epoxide hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Aminopeptidase ltah-1.1
    NP_001023056.1
    • Partially confirmed by transcript evidence
    NP_001023058.1
    • Partially confirmed by transcript evidence
    NP_001367152.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12279660..12281913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027885.5 → NP_001023056.1  Aminopeptidase ltah-1.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023056.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A3QMC1, A3QMC2, G5EFT4
      Conserved Domains (2) summary
      cd09599
      Location:8 → 453
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      pfam09127
      Location:468 → 608
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    2. NM_001380482.2 → NP_001367152.1  Aminopeptidase ltah-1.1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl14813
      Location:8 → 128
      GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    3. NM_001027887.6 → NP_001023058.1  Aminopeptidase ltah-1.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023058.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFT4
      Conserved Domains (3) summary
      cd09599
      Location:8 → 452
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      TIGR02411
      Location:8 → 599
      leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
      pfam09127
      Location:469 → 604
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFT4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.