grk-1 G protein-coupled receptor kinase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: grk-1
Official Full Name: G protein-coupled receptor kinase 1
Primary source: WormBase:WBGene00001708
Locus tag: CELE_F19C6.1
See related: AllianceGenome:WB:WBGene00001708
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein kinase activity. Predicted to be involved in regulation of signal transduction. Predicted to be active in cytoplasm. Is expressed in intestine. Human ortholog(s) of this gene implicated in Oguchi disease-2; Parkinson's disease; congestive heart failure; essential hypertension; and night blindness. Orthologous to several human genes including GRK5 (G protein-coupled receptor kinase 5) and GRK6 (G protein-coupled receptor kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See grk-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 13

Sequence:: Chromosome: X; NC_003284.9 (9991248..9999208, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses.
Title: G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS6-169 (e-PCR)
- UniSTS:242550

F19C6.1 (e-PCR)
- UniSTS:314079

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G protein-coupled receptor kinase 1

NP_509676.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9991248..9999208 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077275.9 → NP_509676.1 G protein-coupled receptor kinase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509676.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09537

Conserved Domains (3) summary

smart00220
Location:203 → 470

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl02565
Location:34 → 196

RGS; Regulator of G protein signaling (RGS) domain superfamily

cl21453
Location:202 → 500

PKc_like; Protein Kinases, catalytic domain