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    tat-4 Phospholipid-transporting ATPase [ Caenorhabditis elegans ]

    Gene ID: 174031, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tat-4
    Official Full Name
    Phospholipid-transporting ATPase
    Primary source
    WormBase:WBGene00020784
    Locus tag
    CELE_T24H7.5
    See related
    AllianceGenome:WB:WBGene00020784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in sterol metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in hermaphrodite gonad; intestine; pharyngeal-intestinal valve; and rectal gland cell. Orthologous to human ATP10A (ATPase phospholipid transporting 10A (putative)); ATP10B (ATPase phospholipid transporting 10B (putative)); and ATP10D (ATPase phospholipid transporting 10D (putative)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tat-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    20
    Sequence:
    Chromosome: II; NC_003280.10 (6234491..6244287, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GyrI-like small molecule binding domain-containing protein Neighboring gene Small vasohibin-binding protein Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 4 Neighboring gene GSKIP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the C. elegans putative aminophospholipid translocases. Lyssenko NN, et al. BMC Dev Biol, 2008 Oct 2. PMID 18831765, Free PMC Article
    2. Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Darland-Ransom M, et al. Science, 2008 Apr 25. PMID 18436785
    3. Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis. Züllig S, et al. Curr Biol, 2007 Jun 5. PMID 17540571
    4. Genome-wide microarrray analysis reveals roles for the REF-1 family member HLH-29 in ferritin synthesis and peroxide stress response. Quach TK, et al. PLoS One, 2013. PMID 23533643, Free PMC Article
    5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phospholipid-transporting ATPase
    NP_001379745.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6234491..6244287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393096.1 → NP_001379745.1  Phospholipid-transporting ATPase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JPE3
      Conserved Domains (1) summary
      cd02073
      Location:65 → 1095
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RNA

    1. NR_165322.1 RNA Sequence

      Status: REVIEWED

    2. NR_165323.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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