wdr-12 Ribosome biogenesis protein WDR12 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wdr-12
Official Full Name: Ribosome biogenesis protein WDR12 homolog
Primary source: WormBase:WBGene00018893
Locus tag: CELE_F55F8.5
See related: AllianceGenome:WB:WBGene00018893
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ribonucleoprotein complex binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of PeBoW complex. Orthologous to human WDR12 (WD repeat domain 12). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See wdr-12 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (5655950..5657917, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F55F8.5 (e-PCR)
- UniSTS:311835

F55F8.6 (e-PCR)
- UniSTS:320560

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ribonucleoprotein complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PeBoW complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ribosome biogenesis protein WDR12 homolog

NP_491655.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5655950..5657917 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059254.8 → NP_491655.1 Ribosome biogenesis protein WDR12 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491655.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91343

Conserved Domains (4) summary

COG2319
Location:202 → 436

WD40; WD40 repeat [General function prediction only]

pfam08154
Location:21 → 88

NLE; NLE (NUC135) domain

sd00039
Location:215 → 277

7WD40; WD40 repeat [structural motif]

cl02567
Location:119 → 437

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...