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    • Showing Current items.

    usp-50 ubiquitinyl hydrolase 1 [ Caenorhabditis elegans ]

    Gene ID: 180175, updated on 14-Nov-2024

    Summary

    Official Symbol
    usp-50
    Official Full Name
    ubiquitinyl hydrolase 1
    Primary source
    WormBase:WBGene00008441
    Locus tag
    CELE_E01B7.1
    See related
    AllianceGenome:WB:WBGene00008441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in ERAD pathway and regulation of protein stability. Predicted to be located in early endosome. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See usp-50 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    17
    Sequence:
    Chromosome: V; NC_003283.11 (17924985..17934218)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Cucumopine_C domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA-Gly Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene Lysine-specific demethylase 9 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Secreted protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitinyl hydrolase 1
    NP_507513.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      17924985..17934218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075112.8NP_507513.2  ubiquitinyl hydrolase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507513.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBW2
      Conserved Domains (2) summary
      pfam00443
      Location:478808
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam08969
      Location:8114
      USP8_dimer; USP8 dimerization domain