eat-6 Sodium/potassium-transporting ATPase subunit alpha [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eat-6
Official Full Name: Sodium/potassium-transporting ATPase subunit alpha
Primary source: WormBase:WBGene00001137
Locus tag: CELE_B0365.3
See related: AllianceGenome:WB:WBGene00001137
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables P-type sodium:potassium-exchanging transporter activity. Involved in several processes, including action potential; establishment or maintenance of transmembrane electrochemical gradient; and metal ion transport. Located in membrane. Is expressed in several structures, including coelomocyte; intestine; neurons; pharynx; and vulval muscle. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD; alternating hemiplegia of childhood; bipolar disorder; brain disease (multiple); and hypertension. Orthologous to several human genes including ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See eat-6 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (13126414..13129995, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

eat-6 (eg200) mutant fails to develop tolerance to ethanol-induced hypercontraction.
Title: A novel cholinergic action of alcohol and the development of tolerance to that effect in Caenorhabditis elegans.
role of eat-6 in modulation of excitatory neurotransmission by 5-HT
Title: A homolog of FHM2 is involved in modulation of excitatory neurotransmission by serotonin in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0365.3 (e-PCR)
- UniSTS:321161

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type potassium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type sodium:potassium-exchanging transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type sodium:potassium-exchanging transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables P-type sodium:potassium-exchanging transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of transmembrane electrochemical gradient	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Sodium/potassium-transporting ATPase subunit alpha

NP_506269.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13126414..13129995 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073868.6 → NP_506269.1 Sodium/potassium-transporting ATPase subunit alpha [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506269.1

Status: REVIEWED

UniProtKB/TrEMBL

P90735, Q27461

Conserved Domains (6) summary

smart00831
Location:18 → 92

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:644 → 725

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:6 → 996

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:112 → 343

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:772 → 981

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:404 → 494

Cation_ATPase; Cation transport ATPase (P-type)