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    lin-9 Protein lin-9 [ Caenorhabditis elegans ]

    Gene ID: 176256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lin-9
    Official Full Name
    Protein lin-9
    Primary source
    WormBase:WBGene00002998
    Locus tag
    CELE_ZK637.7
    See related
    AllianceGenome:WB:WBGene00002998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity. Involved in several processes, including male gonad development; negative regulation of vulval development; and nematode male tail tip morphogenesis. Part of DRM complex. Orthologous to human LIN9 (lin-9 DREAM MuvB core complex component). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lin-9 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (8900237..8904131, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene V-type proton ATPase 116 kDa subunit a 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural Analysis of the ESCRT-III Regulator Lethal(2) Giant Discs/Coiled-Coil and C2 Domain-Containing Protein 1 (Lgd/CC2D1). Breuer T, et al. Cells, 2024 Jul 10. PMID 39056756, Free PMC Article
    2. Gene structure and molecular analysis of Arabidopsis thaliana ALWAYS EARLY homologs. Bhatt AM, et al. Gene, 2004 Jul 21. PMID 15246533
    3. The C. elegans genome sequencing project: a beginning. Sulston J, et al. Nature, 1992 Mar 5. PMID 1538779
    4. The C. elegans gene lin-9,which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein. Beitel GJ, et al. Gene, 2000 Aug 22. PMID 10974557
    5. A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes. Vorster PJ, et al. Biol Open, 2020 May 7. PMID 32295830, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural Analysis of the ESCRT-III Regulator Lethal(2) Giant Discs/Coiled-Coil and C2 Domain-Containing Protein 1 (Lgd/CC2D1).
      Title: Structural Analysis of the ESCRT-III Regulator Lethal(2) Giant Discs/Coiled-Coil and C2 Domain-Containing Protein 1 (Lgd/CC2D1).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DRM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription repressor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein lin-9
    NP_001023015.1
    • Confirmed by transcript evidence
    NP_001023016.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8900237..8904131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027844.5 → NP_001023015.1  Protein lin-9 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023015.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30630
      Conserved Domains (1) summary
      pfam06584
      Location:224 → 330
      DIRP; DIRP

    2. NM_001027845.6 → NP_001023016.1  Protein lin-9 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023016.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30630, Q9NB37, Q9NB38
      Conserved Domains (1) summary
      pfam06584
      Location:226 → 332
      DIRP; DIRP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30630.3

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