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    TCOF1 treacle ribosome biogenesis factor 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 664735, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TCOF1provided by VGNC
    Official Full Name
    treacle ribosome biogenesis factor 1provided by VGNC
    Primary source
    VGNC:VGNC:78294
    See related
    Ensembl:ENSMMUG00000009111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TCOF1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (147870477..147910470)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (148491388..148531300)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin dependent protein kinase II alpha Neighboring gene arylsulfatase family member I Neighboring gene CD74 molecule Neighboring gene ribosomal protein S14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced TCOF1 mRNA level in a rhesus macaque with Treacher Collins-like syndrome: further evidence for haploinsufficiency of treacle as the cause of disease. Shows KH, et al. Mamm Genome, 2006 Feb. PMID 16465596
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    treacle protein
    Names
    Treacher Collins-Franceschetti syndrome 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039952.1 → NP_001035041.1  treacle protein

      Status: PROVISIONAL

      Source sequence(s)
      DQ085095, DQ085096
      UniProtKB/TrEMBL
      A0A1D5RKQ9
      Related
      ENSMMUP00000060903.2, ENSMMUT00000077515.2
      Conserved Domains (2) summary
      smart00667
      Location:6 → 37
      LisH; Lissencephaly type-1-like homology motif
      pfam03546
      Location:388 → 913
      Treacle; Treacher Collins syndrome protein Treacle

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      147870477..147910470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015141160.2 → XP_014996646.2  treacle protein isoform X1

      UniProtKB/TrEMBL
      A0A1D5QVN6, A0A1D5RKQ9
      Related
      ENSMMUP00000052116.2, ENSMMUT00000068743.2
      Conserved Domains (2) summary
      smart00667
      Location:6 → 37
      LisH; Lissencephaly type-1-like homology motif
      pfam03546
      Location:388 → 902
      Treacle; Treacher Collins syndrome protein Treacle

    2. XM_015141162.2 → XP_014996648.2  treacle protein isoform X3

      UniProtKB/TrEMBL
      A0A1D5R7L3, A0A1D5RKQ9
      Related
      ENSMMUP00000056302.2, ENSMMUT00000056185.2
      Conserved Domains (2) summary
      smart00667
      Location:6 → 37
      LisH; Lissencephaly type-1-like homology motif
      pfam03546
      Location:388 → 902
      Treacle; Treacher Collins syndrome protein Treacle

    3. XM_015141164.2 → XP_014996650.2  treacle protein isoform X5

      UniProtKB/TrEMBL
      A0A1D5RKQ9
      Related
      ENSMMUP00000075119.1, ENSMMUT00000087052.1
      Conserved Domains (2) summary
      smart00667
      Location:6 → 37
      LisH; Lissencephaly type-1-like homology motif
      pfam03546
      Location:388 → 902
      Treacle; Treacher Collins syndrome protein Treacle

    4. XM_015141161.2 → XP_014996647.2  treacle protein isoform X2

      UniProtKB/TrEMBL
      A0A1D5R7L3
      Conserved Domains (3) summary
      smart00667
      Location:6 → 37
      LisH; Lissencephaly type-1-like homology motif
      PHA03247
      Location:798 → 1143
      PHA03247; large tegument protein UL36; Provisional
      pfam03546
      Location:388 → 902
      Treacle; Treacher Collins syndrome protein Treacle

    5. XM_028849026.1 → XP_028704859.1  treacle protein isoform X4

      UniProtKB/TrEMBL
      A0A1D5RKQ9
      Conserved Domains (3) summary
      smart00667
      Location:6 → 37
      LisH; Lissencephaly type-1-like homology motif
      PHA03247
      Location:798 → 1240
      PHA03247; large tegument protein UL36; Provisional
      pfam03546
      Location:388 → 902
      Treacle; Treacher Collins syndrome protein Treacle

    6. XM_028849027.1 → XP_028704860.1  treacle protein isoform X6

      UniProtKB/TrEMBL
      A0A1D5R7L3
      Related
      ENSMMUP00000011956.4, ENSMMUT00000012749.4
      Conserved Domains (3) summary
      smart00667
      Location:6 → 37
      LisH; Lissencephaly type-1-like homology motif
      PHA03247
      Location:792 → 1212
      PHA03247; large tegument protein UL36; Provisional
      pfam03546
      Location:388 → 862
      Treacle; Treacher Collins syndrome protein Treacle

    RNA

    1. XR_003730062.1 RNA Sequence

    2. XR_003730063.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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