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    NCK2 NCK adaptor protein 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 713287, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NCK2provided by VGNC
    Official Full Name
    NCK adaptor protein 2provided by VGNC
    Primary source
    VGNC:VGNC:75142
    Locus tag
    EGK_05646
    See related
    Ensembl:ENSMMUG00000001390
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NCK2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (9481914..9632397)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 13 NC_027905.1 (101070489..101221490)

    Chromosome 13 - NC_041766.1Genomic Context describing neighboring genes Neighboring gene chromosome 13 C2orf49 homolog Neighboring gene uncharacterized LOC114671894 Neighboring gene four and a half LIM domains 2 Neighboring gene uncharacterized LOC114671895 Neighboring gene ECRG4 augurin precursor Neighboring gene UDP-glucuronate decarboxylase 1 Neighboring gene 60S ribosomal protein L22 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of PERK-mediated unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytoplasmic protein NCK2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041766.1 Reference Mmul_10 Primary Assembly

      Range
      9481914..9632397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015113048.2 → XP_014968534.1  cytoplasmic protein NCK2 isoform X2

      UniProtKB/TrEMBL
      A0A5F8AJZ6, A0A8J8XPM7, G7NAU9, H9EM59
      Related
      ENSMMUP00000073529.1, ENSMMUT00000093009.1
      Conserved Domains (4) summary
      cd10409
      Location:285 → 382
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:4 → 61
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:116 → 170
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:200 → 258
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    2. XM_015113046.2 → XP_014968532.1  cytoplasmic protein NCK2 isoform X2

      UniProtKB/TrEMBL
      A0A5F8AJZ6, A0A8J8XPM7, G7NAU9, H9EM59
      Related
      ENSMMUP00000077725.1, ENSMMUT00000086118.1
      Conserved Domains (4) summary
      cd10409
      Location:285 → 382
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:4 → 61
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:116 → 170
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:200 → 258
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    3. XM_015113052.2 → XP_014968538.1  cytoplasmic protein NCK2 isoform X4

      Conserved Domains (1) summary
      cd11899
      Location:4 → 61
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein

    4. XM_001109452.4 → XP_001109452.2  cytoplasmic protein NCK2 isoform X2

      See identical proteins and their annotated locations for XP_001109452.2

      UniProtKB/TrEMBL
      A0A5F8AJZ6, A0A8J8XPM7, G7NAU9, H9EM59
      Conserved Domains (4) summary
      cd10409
      Location:285 → 382
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:4 → 61
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:116 → 170
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:200 → 258
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    5. XM_015113047.2 → XP_014968533.1  cytoplasmic protein NCK2 isoform X2

      UniProtKB/TrEMBL
      A0A5F8AJZ6, A0A8J8XPM7, G7NAU9, H9EM59
      Conserved Domains (4) summary
      cd10409
      Location:285 → 382
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:4 → 61
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:116 → 170
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:200 → 258
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    6. XM_015113051.2 → XP_014968537.1  cytoplasmic protein NCK2 isoform X3

      Conserved Domains (1) summary
      cl17036
      Location:15 → 72
      SH3; Src Homology 3 domain superfamily

    7. XM_001109551.4 → XP_001109551.2  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F7D094, H9EM59
      Related
      ENSMMUP00000036193.2, ENSMMUT00000043184.3
      Conserved Domains (4) summary
      cd10409
      Location:296 → 393
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:15 → 72
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:127 → 181
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:211 → 269
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
    Nucleotide Protein
    Heading Accession and Version

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