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    VWF von Willebrand factor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 722019, updated on 17-Aug-2024

    Summary

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    Official Symbol
    VWFprovided by VGNC
    Official Full Name
    von Willebrand factorprovided by VGNC
    Primary source
    VGNC:VGNC:78778
    See related
    Ensembl:ENSMMUG00000022893
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See VWF in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (6082431..6255440, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (6165735..6341448, complement)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene neurotrophin 3 Neighboring gene dynein light chain roadblock-type 1 pseudogene Neighboring gene anoctamin 2 Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene uncharacterized LOC114671034 Neighboring gene uncharacterized LOC114671035

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor. Dang LT, et al. J Biol Chem, 2011 Jul 22. PMID 21592973, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    von Willebrand factor
    Names
    von Willebrandt factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243086.1 → NP_001230015.1  von Willebrand factor precursor

      See identical proteins and their annotated locations for NP_001230015.1

      Status: PROVISIONAL

      Source sequence(s)
      BK007989
      UniProtKB/TrEMBL
      A0A1D5QD20, F5XVB6
      Related
      ENSMMUP00000045939.2, ENSMMUT00000059173.2
      Conserved Domains (12) summary
      smart00041
      Location:2727 → 2808
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:2431 → 2494
      VWC; von Willebrand factor (vWF) type C domain
      smart00216
      Location:377 → 540
      VWD; von Willebrand factor (vWF) type D domain
      smart00327
      Location:1277 → 1449
      VWA; von Willebrand factor (vWF) type A domain
      smart00832
      Location:1053 → 1127
      C8; This domain contains 8 conserved cysteine residues
      pfam00092
      Location:1498 → 1658
      VWA; von Willebrand factor type A domain
      pfam00093
      Location:2582 → 2644
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1950 → 2102
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:652 → 707
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2136 → 2199
      C8; C8 domain
      pfam16164
      Location:1198 → 1276
      VWA_N2; VWA N-terminal
      cl17735
      Location:350 → 394
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      6082431..6255440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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