CHRNB2 cholinergic receptor nicotinic beta 2 subunit [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: CHRNB2provided by VGNC
Official Full Name: cholinergic receptor nicotinic beta 2 subunitprovided by VGNC
Primary source: VGNC:VGNC:71050
See related: Ensembl:ENSMMUG00000016089
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: nicb2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	1	NC_041754.1 (96451151..96464068, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	1	NC_027893.1 (129205214..129218944)

Chromosome 1 - NC_041754.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chronic nicotine exposure up-regulates nAChR activity in developing lung, and that nAChR activity can be further modified by tyrosine phosphorylation.
Title: Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells.

Submit: New GeneRIF Correction

General gene information

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Markers

CHRNB2 (e-PCR)
- UniSTS:479751

RH70833 (e-PCR)
- UniSTS:10514

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in nervous system process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: neuronal acetylcholine receptor subunit beta-2

Names: cholinergic receptor, nicotinic, beta 2 (neuronal); nicotinic acetylcholine receptor subunit beta2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001265649.2 → NP_001252578.1 neuronal acetylcholine receptor subunit beta-2 precursor

See identical proteins and their annotated locations for NP_001252578.1

Status: PROVISIONAL

Source sequence(s)

JV564974

UniProtKB/TrEMBL

G7MDU6, I2CTM4

Related

ENSMMUP00000080762.1, ENSMMUT00000099286.1

Conserved Domains (3) summary

TIGR00860
Location:29 → 479

LIC; Cation transporter family protein

pfam02931
Location:29 → 234

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:241 → 478

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041754.1 Reference Mmul_10 Primary Assembly

Range

96451151..96464068 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015109918.2 → XP_014965404.1 neuronal acetylcholine receptor subunit beta-2 isoform X2

UniProtKB/TrEMBL

F7GMZ4, G7MDU6

Related

ENSMMUP00000021166.3, ENSMMUT00000022627.3

Conserved Domains (3) summary

TIGR00860
Location:29 → 464

LIC; Cation transporter family protein

pfam02931
Location:29 → 219

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:226 → 463

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
XM_015109913.2 → XP_014965399.1 neuronal acetylcholine receptor subunit beta-2 isoform X1

UniProtKB/TrEMBL

G7MDU6

Conserved Domains (3) summary

TIGR00860
Location:82 → 489

LIC; Cation transporter family protein

cd03558
Location:165 → 179

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:81 → 244

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))