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    CYB5R4 cytochrome b5 reductase 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 695553, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CYB5R4provided by VGNC
    Official Full Name
    cytochrome b5 reductase 4provided by VGNC
    Primary source
    VGNC:VGNC:71444
    Locus tag
    EGK_15123
    See related
    Ensembl:ENSMMUG00000009585
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human all
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    Genomic context

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    See CYB5R4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (89132685..89241012, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (82046781..82151250)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 pseudogene Neighboring gene centrosomal protein 162 Neighboring gene ripply transcriptional repressor 2 Neighboring gene synaptosome associated protein 91

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in generation of precursor metabolites and energy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in superoxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome b5 reductase 4
    NP_001180696.1
    XP_014992252.1
    XP_014992254.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193767.2 → NP_001180696.1  cytochrome b5 reductase 4

      See identical proteins and their annotated locations for NP_001180696.1

      Status: PROVISIONAL

      Source sequence(s)
      QNVO02000341
      UniProtKB/TrEMBL
      A0A5F7ZU35, A0A8J8YGS5, G7MPU1, H9ER35
      Related
      ENSMMUP00000068153.1, ENSMMUT00000082489.1
      Conserved Domains (3) summary
      cd06183
      Location:278 → 519
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      cd06490
      Location:170 → 256
      p23_NCB5OR; p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining ...
      pfam00173
      Location:56 → 128
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      89132685..89241012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015136766.2 → XP_014992252.1  cytochrome b5 reductase 4 isoform X1

      UniProtKB/TrEMBL
      A0A1D5REY0, H9ER35
      Related
      ENSMMUP00000058873.1, ENSMMUT00000073590.2
      Conserved Domains (5) summary
      cd06183
      Location:308 → 549
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      cd06490
      Location:170 → 256
      p23_NCB5OR; p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining ...
      PTZ00319
      Location:297 → 549
      PTZ00319; NADH-cytochrome B5 reductase; Provisional
      pfam00173
      Location:56 → 128
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      cl19115
      Location:242 → 309
      Cupredoxin; Cupredoxin superfamily

    2. XM_015136768.2 → XP_014992254.1  cytochrome b5 reductase 4 isoform X2

      UniProtKB/TrEMBL
      F7ADF0
      Conserved Domains (4) summary
      cd06183
      Location:223 → 464
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      cd06490
      Location:85 → 171
      p23_NCB5OR; p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining ...
      pfam00173
      Location:1 → 45
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      cl19115
      Location:157 → 224
      Cupredoxin; Cupredoxin superfamily
    Nucleotide Protein
    Heading Accession and Version

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