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    PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 698857, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PIK3CGprovided by VGNC
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaprovided by VGNC
    Primary source
    VGNC:VGNC:75998
    Locus tag
    EGK_14026
    See related
    Ensembl:ENSMMUG00000011385
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PIK3CG in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (133176857..133220631)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (132279488..132323276)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 71 like Neighboring gene uncharacterized LOC114676760 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta Neighboring gene HMG-box transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IB IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Names
    phosphoinositide-3-kinase, catalytic, gamma polypeptide
    NP_001253687.1
    XP_014990084.1
    XP_014990085.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266758.1 → NP_001253687.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

      See identical proteins and their annotated locations for NP_001253687.1

      Status: PROVISIONAL

      Source sequence(s)
      JU476012
      UniProtKB/TrEMBL
      A0A8J8YMM1, F6W7C8, G7MM34
      Related
      ENSMMUP00000066687.1, ENSMMUT00000103834.1
      Conserved Domains (4) summary
      cd08399
      Location:350 → 527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203 → 312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549 → 725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:729 → 1095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      133176857..133220631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015134599.2 → XP_014990085.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

      UniProtKB/TrEMBL
      A0A8J8YMM1, F6W7C8, G7MM34
      Related
      ENSMMUP00000066301.1, ENSMMUT00000109145.1
      Conserved Domains (4) summary
      cd08399
      Location:350 → 527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203 → 312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549 → 725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:729 → 1095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

    2. XM_015134598.2 → XP_014990084.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

      UniProtKB/TrEMBL
      A0A8J8YMM1, F6W7C8, G7MM34
      Related
      ENSMMUP00000014942.1, ENSMMUT00000015944.3
      Conserved Domains (4) summary
      cd08399
      Location:350 → 527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203 → 312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549 → 725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:729 → 1095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    Nucleotide Protein
    Heading Accession and Version

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