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    NCOA2 nuclear receptor coactivator 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 693455, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NCOA2provided by VGNC
    Official Full Name
    nuclear receptor coactivator 2provided by VGNC
    Primary source
    VGNC:VGNC:75146
    See related
    Ensembl:ENSMMUG00000015978
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NCOA2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (70707484..71004061, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (68291271..68640472, complement)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene PR/SET domain 14 Neighboring gene transcription factor BTF3 pseudogene Neighboring gene 60S ribosomal protein L13 pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene translocation associated membrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor coactivator 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      70707484..71004061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015145551.2 → XP_015001037.1  nuclear receptor coactivator 2 isoform X4

      UniProtKB/TrEMBL
      A0A5F8AQQ8, G7MZI4
      Related
      ENSMMUP00000080285.1, ENSMMUT00000109124.1
      Conserved Domains (10) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      cd00130
      Location:123 → 213
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08430
      Location:1240 → 1358
      Forkhead_N; Forkhead N-terminal region
      pfam00989
      Location:119 → 215
      PAS; PAS fold
      pfam07469
      Location:1212 → 1269
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1002 → 1047
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    2. XM_001082161.4 → XP_001082161.2  nuclear receptor coactivator 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QKI2, G7MZI4, H9ET70
      Conserved Domains (9) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam07469
      Location:1281 → 1338
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:892 → 1372
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    3. XM_028852733.1 → XP_028708566.1  nuclear receptor coactivator 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QKI2, G7MZI4, H9ET70
      Related
      ENSMMUP00000048555.2, ENSMMUT00000053746.2
      Conserved Domains (9) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam07469
      Location:1281 → 1338
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:892 → 1372
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    4. XM_028852728.1 → XP_028708561.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      G7MZI4
      Conserved Domains (9) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam07469
      Location:1351 → 1407
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:1135 → 1484
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    5. XM_028852734.1 → XP_028708567.1  nuclear receptor coactivator 2 isoform X3

      UniProtKB/TrEMBL
      G7MZI4
      Related
      ENSMMUP00000064603.1, ENSMMUT00000087488.1
      Conserved Domains (9) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam07469
      Location:1282 → 1338
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1002 → 1047
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:1066 → 1415
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    6. XM_028852729.1 → XP_028708562.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      G7MZI4
      Conserved Domains (9) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam07469
      Location:1351 → 1407
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:1135 → 1484
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    7. XM_028852730.1 → XP_028708563.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      G7MZI4
      Related
      ENSMMUP00000071891.1, ENSMMUT00000104457.1
      Conserved Domains (9) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam07469
      Location:1351 → 1407
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:1135 → 1484
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    8. XM_028852731.1 → XP_028708564.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      G7MZI4
      Conserved Domains (9) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam07469
      Location:1351 → 1407
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:1135 → 1484
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    9. XM_028852732.1 → XP_028708565.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      G7MZI4
      Conserved Domains (9) summary
      smart00353
      Location:35 → 88
      HLH; helix loop helix domain
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam07469
      Location:1351 → 1407
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640 → 709
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:1135 → 1484
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    Nucleotide Protein
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