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    PDGFB platelet derived growth factor subunit B [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 703173, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PDGFBprovided by VGNC
    Official Full Name
    platelet derived growth factor subunit Bprovided by VGNC
    Primary source
    VGNC:VGNC:75927
    Locus tag
    EGK_03057
    See related
    Ensembl:ENSMMUG00000002739
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PDGFB in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (12323195..12347665)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (81199695..81223286, complement)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U83B Neighboring gene small nucleolar RNA U83B Neighboring gene ribosomal protein L3 Neighboring gene uncharacterized LOC107000666 Neighboring gene chromobox 7 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of platelet-derived growth factor-B expression in the ventral horn and motor cortex in the spinal cord-hemisected rhesus monkey. Xiyang YB, et al. J Neurotrauma, 2009 Feb 11. PMID 19236168
    2. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. intrinsic PDGF-B expressed in the spinal cord may play an essential role in neuroregulation in primates following cord hemisection
      Title: Roles of platelet-derived growth factor-B expression in the ventral horn and motor cortex in the spinal cord-hemisected rhesus monkey.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables platelet-derived growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet-derived growth factor subunit B
    Names
    platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      12323195..12347665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001097395.4 → XP_001097395.1  platelet-derived growth factor subunit B

      See identical proteins and their annotated locations for XP_001097395.1

      UniProtKB/TrEMBL
      A0A1D5Q4I7, A0A8J8XHM2, F7HKP4, G7N3W3, H9F8C0
      Related
      ENSMMUP00000042951.2, ENSMMUT00000060165.2
      Conserved Domains (2) summary
      pfam00341
      Location:97 → 180
      PDGF; PDGF/VEGF domain
      pfam04692
      Location:21 → 93
      PDGF_N; Platelet-derived growth factor, N terminal region
    Nucleotide Protein
    Heading Accession and Version

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