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    ITCH itchy E3 ubiquitin protein ligase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707640, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ITCHprovided by VGNC
    Official Full Name
    itchy E3 ubiquitin protein ligaseprovided by VGNC
    Primary source
    VGNC:VGNC:73589
    See related
    Ensembl:ENSMMUG00000012912
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ITCH in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (69569727..69707513)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (29636725..29775793, complement)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene adenosylhomocysteinase Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene cell division control protein 42 homolog pseudogene Neighboring gene microRNA mir-644 Neighboring gene dynein light chain roadblock-type 1 Neighboring gene microtubule associated protein 1 light chain 3 alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein K29-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase Itchy homolog
    Names
    e3 ubiquitin-protein ligase Itchy homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      69569727..69707513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015149167.1 → XP_015004653.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      F6S0K0, G7N508, H9ERF6
      Related
      ENSMMUP00000074218.1, ENSMMUT00000098033.1
      Conserved Domains (3) summary
      cd04021
      Location:17 → 140
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:318 → 862
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:287 → 316
      WW; WW domain

    2. XM_028828339.1 → XP_028684172.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      F6S0K0, G7N508, H9ERF6
      Related
      ENSMMUP00000079499.1, ENSMMUT00000108820.1
      Conserved Domains (3) summary
      cd04021
      Location:17 → 140
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:318 → 862
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:287 → 316
      WW; WW domain

    3. XM_015149172.2 → XP_015004658.1  E3 ubiquitin-protein ligase Itchy homolog isoform X3

      Conserved Domains (4) summary
      smart00456
      Location:268 → 299
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:361 → 689
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:337 → 690
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:229 → 258
      WW; WW domain

    4. XM_015149170.2 → XP_015004656.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

      UniProtKB/TrEMBL
      G7N508
      Conserved Domains (2) summary
      COG5021
      Location:229 → 773
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:198 → 227
      WW; WW domain

    5. XM_015149171.2 → XP_015004657.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

      UniProtKB/TrEMBL
      G7N508
      Conserved Domains (2) summary
      COG5021
      Location:229 → 773
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:198 → 227
      WW; WW domain

    6. XM_015149173.1 → XP_015004659.1  E3 ubiquitin-protein ligase Itchy homolog isoform X4

      Conserved Domains (1) summary
      COG5021
      Location:57 → 508
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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