CNR1 cannabinoid receptor 1 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: CNR1provided by VGNC
Official Full Name: cannabinoid receptor 1provided by VGNC
Primary source: VGNC:VGNC:71280
Locus tag: EGK_15153
See related: Ensembl:ENSMMUG00000000763
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	4	NC_041757.1 (85188814..85190232)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	4	NC_027896.1 (86259855..86261273, complement)

Chromosome 4 - NC_041757.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of the type 1 cannabinoid receptor (CB1R) in CCK-immunoreactive axon terminals in the basolateral amygdala of the rhesus monkey (Macaca mulatta).
Title: Expression of the type 1 cannabinoid receptor (CB1R) in CCK-immunoreactive axon terminals in the basolateral amygdala of the rhesus monkey (Macaca mulatta).
Cannabinoid Type 1 Receptor is Undetectable in Rodent and Primate Cerebral Neural Stem Cells but Participates in Radial Neuronal Migration.
Title: Cannabinoid Type 1 Receptor is Undetectable in Rodent and Primate Cerebral Neural Stem Cells but Participates in Radial Neuronal Migration.
The downregulation of cannabinoid receptor 1 and upregulation of monoglycerol lipase and fatty acid amide hydrolase in PVN was involved in the pathogenesis of type 2 diabetes.
Title: Endocannabinoid hydrolase and cannabinoid receptor 1 are involved in the regulation of hypothalamus-pituitary-adrenal axis in type 2 diabetes.
This study provides unique evidence that the CB1R is dynamically and progressively involved from the start of mesial temporal lobe epileptogenesis
Title: Positron emission tomography imaging of cerebral glucose metabolism and type 1 cannabinoid receptor availability during temporal lobe epileptogenesis in the amygdala kindling model in rhesus monkeys.
The result of this study provided a potential substrate for discrete, age-dependent effects of cannabinoid 1 receptor expression on the maturation of primate DLPFC circuitry.
Title: Development of cannabinoid 1 receptor protein and messenger RNA in monkey dorsolateral prefrontal cortex.

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General gene information

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Markers

RH70837 (e-PCR)
- UniSTS:57635

UniSTS:482606 (e-PCR)
- UniSTS:482606

WI-19695 (e-PCR)
- UniSTS:70980

CNR1 (e-PCR)
- UniSTS:479925

NoName (e-PCR)
- UniSTS:482039

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cannabinoid receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cannabinoid receptor 1

Names: CB-R; CB1; cannabinoid receptor CB-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001032825.1 → NP_001027997.1 cannabinoid receptor 1

See identical proteins and their annotated locations for NP_001027997.1

Status: PROVISIONAL

Source sequence(s)

AF286025

UniProtKB/Swiss-Prot

Q71SP5

UniProtKB/TrEMBL

A0A5F8AA37, A0A8J8Y3J7, G7MPW5, H9ENC0

Related

ENSMMUP00000001031.4, ENSMMUT00000001100.4

Conserved Domains (1) summary

cd15340
Location:117 → 408

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors