SYNE2 spectrin repeat containing nuclear envelope protein 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Gene symbol: SYNE2
Gene description: spectrin repeat containing nuclear envelope protein 2
See related: Ensembl:ENSMMUG00000001008
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 118

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	7	NC_041760.1 (125930118..126306213)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	7	NC_027899.1 (125803027..126182659)

Chromosome 7 - NC_041760.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

SHGC-63651 (e-PCR)
- UniSTS:42307

G35494 (e-PCR)
- UniSTS:70221

G35984 (e-PCR)
- UniSTS:16769

D14S754 (e-PCR)
- UniSTS:6564

G35596 (e-PCR)
- UniSTS:57775

A004F18 (e-PCR)
- UniSTS:21953

RH102390 (e-PCR)
- UniSTS:96724

SHGC-33866 (e-PCR)
- UniSTS:31450

D14S636E (e-PCR)
- UniSTS:151541

SYNE2_9322 (e-PCR)
- UniSTS:468733

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nesprin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041760.1 Reference Mmul_10 Primary Assembly

Range

125930118..126306213

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_028851601.1 → XP_028707434.1 nesprin-2 isoform X1

UniProtKB/TrEMBL

G7MY99

Conserved Domains (8) summary

COG1196
Location:2284 → 2617

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:28 → 279

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:1418 → 2014

PRK03918; chromosome segregation protein; Provisional

cd00176
Location:6139 → 6352

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1898 → 2635

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:2805 → 3420

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:6879 → 6910

KASH; Nuclear envelope localization domain

cl02488
Location:5180 → 5386

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_028851602.1 → XP_028707435.1 nesprin-2 isoform X2

UniProtKB/TrEMBL

A0A5F7ZRW7, G7MY99

Related

ENSMMUP00000067895.1, ENSMMUT00000086324.1

Conserved Domains (8) summary

COG1196
Location:2284 → 2617

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:28 → 279

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:1418 → 2014

PRK03918; chromosome segregation protein; Provisional

cd00176
Location:6139 → 6352

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1898 → 2635

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:2805 → 3420

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:6878 → 6909

KASH; Nuclear envelope localization domain

cl02488
Location:5180 → 5386

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_028851605.1 → XP_028707438.1 nesprin-2 isoform X5

UniProtKB/TrEMBL

G7MY99

Conserved Domains (8) summary

COG1196
Location:2284 → 2617

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:28 → 279

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:1418 → 2014

PRK03918; chromosome segregation protein; Provisional

cd00176
Location:6139 → 6352

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1898 → 2635

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:2805 → 3420

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:6856 → 6887

KASH; Nuclear envelope localization domain

cl02488
Location:5180 → 5386

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_028851606.1 → XP_028707439.1 nesprin-2 isoform X6

UniProtKB/TrEMBL

F6SQE4, G7MY99

Related

ENSMMUP00000001353.4, ENSMMUT00000001438.4

Conserved Domains (8) summary

COG1196
Location:2284 → 2617

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:28 → 279

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:1418 → 2014

PRK03918; chromosome segregation protein; Provisional

cd00176
Location:6139 → 6352

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1898 → 2635

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:2805 → 3420

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:6855 → 6886

KASH; Nuclear envelope localization domain

cl02488
Location:5180 → 5386

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_028851604.1 → XP_028707437.1 nesprin-2 isoform X4

UniProtKB/TrEMBL

G7MY99

Conserved Domains (8) summary

COG1196
Location:2284 → 2617

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:28 → 279

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:1418 → 2014

PRK03918; chromosome segregation protein; Provisional

cd00176
Location:6137 → 6350

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1898 → 2635

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:2805 → 3420

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:6876 → 6907

KASH; Nuclear envelope localization domain

cl02488
Location:5178 → 5384

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_028851607.1 → XP_028707440.1 nesprin-2 isoform X7

UniProtKB/TrEMBL

G7MY99

Conserved Domains (8) summary

COG1196
Location:2284 → 2617

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:28 → 279

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:1418 → 2014

PRK03918; chromosome segregation protein; Provisional

cd00176
Location:6137 → 6350

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1898 → 2635

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:2805 → 3420

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:6854 → 6885

KASH; Nuclear envelope localization domain

cl02488
Location:5178 → 5384

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_028851603.1 → XP_028707436.1 nesprin-2 isoform X3

UniProtKB/TrEMBL

G7MY99

Conserved Domains (8) summary

COG1196
Location:2284 → 2617

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:28 → 279

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:1418 → 2014

PRK03918; chromosome segregation protein; Provisional

cd00176
Location:6137 → 6350

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1898 → 2635

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:2805 → 3420

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:6877 → 6908

KASH; Nuclear envelope localization domain

cl02488
Location:5178 → 5384

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_028851608.1 → XP_028707441.1 nesprin-2 isoform X8

UniProtKB/TrEMBL

A0A1D5R2A3, F7BVB8

Related

ENSMMUP00000032873.3, ENSMMUT00000039806.3

Conserved Domains (8) summary

COG1196
Location:2284 → 2617

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:28 → 279

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:1418 → 2014

PRK03918; chromosome segregation protein; Provisional

cd00176
Location:6102 → 6315

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1898 → 2635

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:2805 → 3420

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:6842 → 6873

KASH; Nuclear envelope localization domain

cl02488
Location:5143 → 5349

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_015143879.2 → XP_014999365.2 nesprin-2 isoform X1

UniProtKB/TrEMBL

G7MY99

Conserved Domains (8) summary

COG1196
Location:2284 → 2617

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:28 → 279

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:1418 → 2014

PRK03918; chromosome segregation protein; Provisional

cd00176
Location:6139 → 6352

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1898 → 2635

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:2805 → 3420

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:6879 → 6910

KASH; Nuclear envelope localization domain

cl02488
Location:5180 → 5386

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_015143880.2 → XP_014999366.2 nesprin-2 isoform X9

Conserved Domains (5) summary

COG0419
Location:439 → 1014

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:1113 → 1877

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:1940 → 2153

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam10541
Location:2680 → 2711

KASH; Nuclear envelope localization domain

cl02488
Location:981 → 1187

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_015143881.2 → XP_014999367.2 nesprin-2 isoform X10

Conserved Domains (2) summary

cd00176
Location:131 → 344

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam10541
Location:871 → 902

KASH; Nuclear envelope localization domain