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    PRKDC protein kinase, DNA-activated, catalytic subunit [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 708029, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PRKDCprovided by VGNC
    Official Full Name
    protein kinase, DNA-activated, catalytic subunitprovided by VGNC
    Primary source
    VGNC:VGNC:76418
    See related
    Ensembl:ENSMMUG00000015347
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PRKDC in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    86
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (48331662..48521183, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (45287699..45476950, complement)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene scaffold protein involved in DNA repair Neighboring gene U6 spliceosomal RNA Neighboring gene CCAAT enhancer binding protein delta Neighboring gene U6 spliceosomal RNA Neighboring gene minichromosome maintenance complex component 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-dependent protein kinase catalytic subunit
    Names
    protein kinase, DNA-activated, catalytic polypeptide
    XP_015000813.1
    XP_015000814.1
    XP_015000815.1
    XP_015000816.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      48331662..48521183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015145327.1 → XP_015000813.1  DNA-dependent protein kinase catalytic subunit isoform X1

      UniProtKB/TrEMBL
      G7MZ94
      Conserved Domains (4) summary
      cd05172
      Location:3720 → 4016
      PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
      pfam02259
      Location:3024 → 3471
      FAT; FAT domain
      pfam02260
      Location:4098 → 4129
      FATC; FATC domain
      pfam08163
      Location:1815 → 2202
      NUC194; NUC194 domain

    2. XM_015145329.2 → XP_015000815.1  DNA-dependent protein kinase catalytic subunit isoform X3

      UniProtKB/TrEMBL
      H9F7A9
      Conserved Domains (4) summary
      cd05172
      Location:3720 → 3985
      PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
      pfam02259
      Location:3024 → 3471
      FAT; FAT domain
      pfam02260
      Location:4067 → 4098
      FATC; FATC domain
      pfam08163
      Location:1815 → 2202
      NUC194; NUC194 domain

    3. XM_015145330.2 → XP_015000816.1  DNA-dependent protein kinase catalytic subunit isoform X4

      UniProtKB/TrEMBL
      F6SNY4, H9F7A9
      Related
      ENSMMUP00000020136.4, ENSMMUT00000021529.4
      Conserved Domains (4) summary
      cd05172
      Location:3719 → 3984
      PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
      pfam02259
      Location:3023 → 3470
      FAT; FAT domain
      pfam02260
      Location:4066 → 4097
      FATC; FATC domain
      pfam08163
      Location:1815 → 2202
      NUC194; NUC194 domain

    4. XM_015145328.2 → XP_015000814.1  DNA-dependent protein kinase catalytic subunit isoform X2

      UniProtKB/TrEMBL
      F6SP41, G7MZ94
      Related
      ENSMMUP00000020132.3, ENSMMUT00000021524.4
      Conserved Domains (4) summary
      cd05172
      Location:3719 → 4015
      PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
      pfam02259
      Location:3023 → 3470
      FAT; FAT domain
      pfam02260
      Location:4097 → 4128
      FATC; FATC domain
      pfam08163
      Location:1815 → 2202
      NUC194; NUC194 domain
    Nucleotide Protein
    Heading Accession and Version

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