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    MAMU-DPB major histocompatibility complex, class II, DP beta [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 717969, updated on 5-Mar-2024

    Summary

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    Gene symbol
    MAMU-DPB
    Gene description
    major histocompatibility complex, class II, DP beta
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    Mamu-DPB1
    Orthologs
    human all
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    Genomic context

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    See MAMU-DPB in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (136417890..136429207, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (33920842..33932245)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene collagen type XI alpha 2 chain Neighboring gene uncharacterized LOC106997910 Neighboring gene uncharacterized LOC114677627 Neighboring gene uncharacterized LOC106997908 Neighboring gene major histocompatibility complex, class II, DP alpha Neighboring gene elongation factor 1-alpha 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Allelic diversity at the Mhc-DP locus in rhesus macaques (Macaca mulatta). Slierendregt BL, et al. Immunogenetics, 1995. PMID 7806271
    2. Characterization and distribution of Mhc-DPB1 alleles in chimpanzee and rhesus macaque populations. Otting N, et al. Hum Immunol, 1998 Oct. PMID 9757948
    3. The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers. Giraldo-Vela JP, et al. J Virol, 2008 Jan. PMID 17989178, Free PMC Article
    4. Molecular mechanism and cellular function of MHCII ubiquitination. Oh J, et al. Immunol Rev, 2015 Jul. PMID 26085212, Free PMC Article
    5. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major histocompatibility complex, class II, DP beta
    Names
    MHC class II antigen
    MHC class II protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361236.2 → NP_001348165.2  major histocompatibility complex, class II, DP beta precursor

      Status: VALIDATED

      Source sequence(s)
      QNVO02000341
      UniProtKB/TrEMBL
      A0A0M7BGI9, U6EFQ2
      Conserved Domains (2) summary
      pfam00969
      Location:42 → 112
      MHC_II_beta; Class II histocompatibility antigen, beta domain
      cd21003
      Location:121 → 216
      IgC1_MHC_II_beta_HLA-DP; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain of histocompatibility antigen (HLA) DP; member of the C1-set of Ig superfamily (IgSF) domains

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      136417890..136429207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015136096.2 → XP_014991582.2  major histocompatibility complex, class II, DP beta

      Conserved Domains (2) summary
      pfam00969
      Location:42 → 112
      MHC_II_beta; Class II histocompatibility antigen, beta domain
      cd21003
      Location:121 → 216
      IgC1_MHC_II_beta_HLA-DP; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain of histocompatibility antigen (HLA) DP; member of the C1-set of Ig superfamily (IgSF) domains
    Nucleotide Protein
    Heading Accession and Version

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