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    MBTPS2 membrane bound transcription factor peptidase, site 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 696540, updated on 5-Mar-2024

    Summary

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    Gene symbol
    MBTPS2
    Gene description
    membrane bound transcription factor peptidase, site 2
    See related
    Ensembl:ENSMMUG00000022467
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See MBTPS2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) X NC_041774.1 (21612978..21658872)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) X NC_027913.1 (21265569..21324121)

    Chromosome X - NC_041774.1Genomic Context describing neighboring genes Neighboring gene small muscle protein X-linked Neighboring gene dnaJ homolog subfamily A member 1 pseudogene Neighboring gene YY2 transcription factor Neighboring gene spermine synthase Neighboring gene phosphate regulating endopeptidase X-linked Neighboring gene uncharacterized LOC114674658

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in membrane protein intracellular domain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    membrane-bound transcription factor site-2 protease
    XP_014982566.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041774.1 Reference Mmul_10 Primary Assembly

      Range
      21612978..21658872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015127080.2 → XP_014982566.1  membrane-bound transcription factor site-2 protease

      UniProtKB/TrEMBL
      G7NSN8
      Related
      ENSMMUP00000029553.3, ENSMMUT00000031589.4
      Conserved Domains (2) summary
      cd06162
      Location:18 → 230
      S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
      pfam02163
      Location:160 → 501
      Peptidase_M50; Peptidase family M50
    Nucleotide Protein
    Heading Accession and Version

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