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    CD4 CD4 molecule [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 713807, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CD4provided by VGNC
    Official Full Name
    CD4 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:99912
    See related
    Ensembl:ENSMMUG00000013202
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CD4 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (6953431..6986331)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (7097437..7129417)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene parathymosin Neighboring gene lymphocyte activating 3 Neighboring gene G protein-coupled receptor 162 Neighboring gene prolyl 3-hydroxylase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence and functional properties of African green monkey CD4 silencer. Matsunaga S, et al. Immunol Lett, 2000 Dec 1. PMID 11163866
    2. Nuclear gene trees and the phylogenetic relationships of the mangabeys (Primates: Papionini). Harris EE, et al. Mol Biol Evol, 1998 Jul. PMID 9656488
    3. Position-dependent variegation of a CD4 minigene with targeted expression to mature CD4+ T cells. Boyer O, et al. J Immunol, 1997 Oct 1. PMID 9317137
    4. CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo. Francella N, et al. J Virol, 2013 Sep. PMID 23824793, Free PMC Article
    5. Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5. Roop JI, et al. Viruses, 2020 Feb 21. PMID 32098152, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5.
      Title: Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5.
    2. The absence of CD4 T cells results in failure to produce antibodies that neutralize CD4-independent SIV Envs and CD4-pretriggered control SIV Envs.
      Title: CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in interleukin-15-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD4
    Names
    CD4 antigen
    T-cell surface antigen T4/Leu-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042662.1 → NP_001036127.1  T-cell surface glycoprotein CD4 precursor

      See identical proteins and their annotated locations for NP_001036127.1

      Status: PROVISIONAL

      Source sequence(s)
      M31134
      UniProtKB/Swiss-Prot
      P16003, Q29617
      Conserved Domains (5) summary
      smart00410
      Location:129 → 201
      IG_like; Immunoglobulin like
      pfam05790
      Location:317 → 389
      C2-set; Immunoglobulin C2-set domain
      pfam09191
      Location:208 → 316
      CD4-extracel; CD4, extracellular
      pfam12104
      Location:426 → 453
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      cl11960
      Location:28 → 109
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      6953431..6986331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015150817.2 → XP_015006303.2  T-cell surface glycoprotein CD4 isoform X1

      UniProtKB/TrEMBL
      A0A2Z5GBT8, F6XGD3, H9G1S6
      Related
      ENSMMUP00000017342.4, ENSMMUT00000018518.4
      Conserved Domains (4) summary
      pfam05790
      Location:317 → 389
      C2-set; Immunoglobulin C2-set domain
      pfam12104
      Location:426 → 453
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      pfam09191
      Location:208 → 316
      CD4-extracel; CD4, extracellular
      cl11960
      Location:28 → 109
      Ig; Immunoglobulin domain

    2. XM_015150818.2 → XP_015006304.2  T-cell surface glycoprotein CD4 isoform X1

      UniProtKB/TrEMBL
      A0A2Z5GBT8, F6XGD3, H9G1S6
      Related
      ENSMMUP00000069370.1, ENSMMUT00000104352.1
      Conserved Domains (4) summary
      pfam05790
      Location:317 → 389
      C2-set; Immunoglobulin C2-set domain
      pfam12104
      Location:426 → 453
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      pfam09191
      Location:208 → 316
      CD4-extracel; CD4, extracellular
      cl11960
      Location:28 → 109
      Ig; Immunoglobulin domain

    3. XM_028828990.1 → XP_028684823.1  T-cell surface glycoprotein CD4 isoform X1

      UniProtKB/TrEMBL
      A0A2Z5GBT8, F6XGD3, H9G1S6
      Conserved Domains (4) summary
      pfam05790
      Location:317 → 389
      C2-set; Immunoglobulin C2-set domain
      pfam12104
      Location:426 → 453
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      pfam09191
      Location:208 → 316
      CD4-extracel; CD4, extracellular
      cl11960
      Location:28 → 109
      Ig; Immunoglobulin domain

    4. XM_015150821.2 → XP_015006307.2  T-cell surface glycoprotein CD4 isoform X3

      Conserved Domains (3) summary
      pfam05790
      Location:44 → 116
      C2-set; Immunoglobulin C2-set domain
      pfam12104
      Location:153 → 180
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      cl11960
      Location:1 → 43
      Ig; Immunoglobulin domain

    5. XM_015150820.2 → XP_015006306.2  T-cell surface glycoprotein CD4 isoform X2

      UniProtKB/TrEMBL
      A0A5F8A870
      Related
      ENSMMUP00000074062.1, ENSMMUT00000087657.1
      Conserved Domains (3) summary
      pfam05790
      Location:138 → 210
      C2-set; Immunoglobulin C2-set domain
      pfam12104
      Location:247 → 274
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      pfam09191
      Location:29 → 137
      CD4-extracel; CD4, extracellular
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16003.2 GenPept UniProtKB/Swiss-Prot:P16003

    Gene LinkOut

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