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    ITSN2 intersectin 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 704858, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ITSN2provided by VGNC
    Official Full Name
    intersectin 2provided by VGNC
    Primary source
    VGNC:VGNC:73807
    See related
    Ensembl:ENSMMUG00000009408
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ITSN2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (84629687..84787398)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 13 NC_027905.1 (24425862..24583432, complement)

    Chromosome 13 - NC_041766.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 1 Neighboring gene U6 spliceosomal RNA Neighboring gene spidroin-1-like Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene 60S ribosomal protein L36a-like Neighboring gene small Cajal body-specific RNA 21 Neighboring gene family with sequence similarity 228 member A Neighboring gene family with sequence similarity 228 member B Neighboring gene profilin family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endosomal transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intracellular vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    intersectin-2
    Names
    intersectin-2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041766.1 Reference Mmul_10 Primary Assembly

      Range
      84629687..84787398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015111819.2 → XP_014967305.1  intersectin-2 isoform X1

      UniProtKB/TrEMBL
      H9FV25
      Conserved Domains (16) summary
      cd08375
      Location:1555 → 1689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:759 → 815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902 → 953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:985 → 1036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1057 → 1115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1130 → 1183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:248 → 314
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:1420 → 1552
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00621
      Location:1214 → 1394
      RhoGEF; RhoGEF domain
      pfam03763
      Location:684 → 751
      Remorin_C; Remorin, C-terminal region
      pfam13499
      Location:249 → 306
      EF-hand_7; EF-hand domain pair
      pfam13868
      Location:383 → 741
      TPH; Trichohyalin-plectin-homology domain
      pfam16617
      Location:815 → 902
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:470 → 481
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:379 → 490
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_015111820.2 → XP_014967306.1  intersectin-2 isoform X2

      UniProtKB/TrEMBL
      H9FV25
      Conserved Domains (16) summary
      cd08375
      Location:1542 → 1676
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:746 → 802
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:889 → 940
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:972 → 1023
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1044 → 1102
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1117 → 1170
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:248 → 314
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:1407 → 1539
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00621
      Location:1201 → 1381
      RhoGEF; RhoGEF domain
      pfam13499
      Location:249 → 306
      EF-hand_7; EF-hand domain pair
      pfam13868
      Location:383 → 740
      TPH; Trichohyalin-plectin-homology domain
      pfam16617
      Location:802 → 889
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:470 → 481
      GBP_C; coiled coil [structural motif]
      cl01868
      Location:662 → 734
      YukC; WXG100 protein secretion system (Wss), protein YukC
      cl20817
      Location:379 → 490
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. XM_028831933.1 → XP_028687766.1  intersectin-2 isoform X5

      UniProtKB/TrEMBL
      H9FV25
      Conserved Domains (10) summary
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:759 → 815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902 → 953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:985 → 1036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1057 → 1115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1130 → 1183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:1214 → 1394
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16617
      Location:815 → 902
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1412 → 1534
      PH_13; Pleckstrin homology domain
      pfam17380
      Location:379 → 754
      DUF5401; Family of unknown function (DUF5401)

    4. XM_028831935.1 → XP_028687768.1  intersectin-2 isoform X6

      UniProtKB/TrEMBL
      H9FV25
      Conserved Domains (9) summary
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:759 → 815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902 → 953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:985 → 1036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1057 → 1115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1130 → 1183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00160
      Location:1210 → 1363
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:815 → 902
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam17380
      Location:379 → 754
      DUF5401; Family of unknown function (DUF5401)

    5. XM_028831934.1 → XP_028687767.1  intersectin-2 isoform X6

      UniProtKB/TrEMBL
      H9FV25
      Conserved Domains (9) summary
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:759 → 815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902 → 953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:985 → 1036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1057 → 1115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1130 → 1183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00160
      Location:1210 → 1363
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:815 → 902
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam17380
      Location:379 → 754
      DUF5401; Family of unknown function (DUF5401)

    6. XM_015111816.2 → XP_014967302.1  intersectin-2 isoform X1

      UniProtKB/TrEMBL
      H9FV25
      Conserved Domains (16) summary
      cd08375
      Location:1555 → 1689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:759 → 815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902 → 953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:985 → 1036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1057 → 1115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1130 → 1183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:248 → 314
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:1420 → 1552
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00621
      Location:1214 → 1394
      RhoGEF; RhoGEF domain
      pfam03763
      Location:684 → 751
      Remorin_C; Remorin, C-terminal region
      pfam13499
      Location:249 → 306
      EF-hand_7; EF-hand domain pair
      pfam13868
      Location:383 → 741
      TPH; Trichohyalin-plectin-homology domain
      pfam16617
      Location:815 → 902
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:470 → 481
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:379 → 490
      GBP_C; Guanylate-binding protein, C-terminal domain

    7. XM_015111821.2 → XP_014967307.1  intersectin-2 isoform X3

      UniProtKB/TrEMBL
      H9FV26
      Conserved Domains (16) summary
      cd08375
      Location:1528 → 1662
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:732 → 788
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:875 → 926
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:958 → 1009
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1030 → 1088
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1103 → 1156
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:248 → 314
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:1393 → 1525
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00621
      Location:1187 → 1367
      RhoGEF; RhoGEF domain
      pfam00992
      Location:579 → 714
      Troponin; Troponin
      pfam13499
      Location:249 → 306
      EF-hand_7; EF-hand domain pair
      pfam16617
      Location:788 → 875
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:470 → 481
      GBP_C; coiled coil [structural motif]
      cl01868
      Location:615 → 707
      YukC; WXG100 protein secretion system (Wss), protein YukC
      cl20817
      Location:379 → 490
      GBP_C; Guanylate-binding protein, C-terminal domain

    8. XM_015111822.2 → XP_014967308.1  intersectin-2 isoform X4

      UniProtKB/TrEMBL
      A0A1D5Q404, H9FV26
      Related
      ENSMMUP00000042767.2, ENSMMUT00000070880.2
      Conserved Domains (16) summary
      cd08375
      Location:1515 → 1649
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:719 → 775
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:862 → 913
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:945 → 996
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1017 → 1075
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1090 → 1143
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:248 → 314
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:1380 → 1512
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00621
      Location:1174 → 1354
      RhoGEF; RhoGEF domain
      pfam00992
      Location:579 → 714
      Troponin; Troponin
      pfam13499
      Location:249 → 306
      EF-hand_7; EF-hand domain pair
      pfam16617
      Location:775 → 862
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:470 → 481
      GBP_C; coiled coil [structural motif]
      cl01868
      Location:615 → 707
      YukC; WXG100 protein secretion system (Wss), protein YukC
      cl20817
      Location:379 → 490
      GBP_C; Guanylate-binding protein, C-terminal domain

    9. XM_015111818.2 → XP_014967304.1  intersectin-2 isoform X1

      UniProtKB/TrEMBL
      H9FV25
      Related
      ENSMMUP00000012316.4, ENSMMUT00000013139.4
      Conserved Domains (16) summary
      cd08375
      Location:1555 → 1689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15 → 107
      EH; Eps15 homology domain
      cd11988
      Location:759 → 815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902 → 953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:985 → 1036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:1057 → 1115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:1130 → 1183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:248 → 314
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:1420 → 1552
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00621
      Location:1214 → 1394
      RhoGEF; RhoGEF domain
      pfam03763
      Location:684 → 751
      Remorin_C; Remorin, C-terminal region
      pfam13499
      Location:249 → 306
      EF-hand_7; EF-hand domain pair
      pfam13868
      Location:383 → 741
      TPH; Trichohyalin-plectin-homology domain
      pfam16617
      Location:815 → 902
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:470 → 481
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:379 → 490
      GBP_C; Guanylate-binding protein, C-terminal domain

    RNA

    1. XR_001438967.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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