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    PDGFC platelet derived growth factor C [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 700236, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PDGFCprovided by VGNC
    Official Full Name
    platelet derived growth factor Cprovided by VGNC
    Primary source
    VGNC:VGNC:75928
    See related
    Ensembl:ENSMMUG00000022900
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PDGFC in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (154396282..154615849, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (156754297..156974175, complement)

    Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene 60S ribosomal protein L10-like Neighboring gene vesicle-associated membrane protein-associated protein B/C pseudogene Neighboring gene 60S ribosomal protein L14 Neighboring gene glycine receptor beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables platelet-derived growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet-derived growth factor C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041758.1 Reference Mmul_10 Primary Assembly

      Range
      154396282..154615849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001093265.3 → XP_001093265.1  platelet-derived growth factor C

      UniProtKB/TrEMBL
      A0A5F8ASK5, F6WES5
      Related
      ENSMMUP00000080057.1, ENSMMUT00000107764.1
      Conserved Domains (2) summary
      cd00041
      Location:49 → 162
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00135
      Location:248 → 340
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials