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    SYK spleen associated tyrosine kinase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 704102, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SYKprovided by VGNC
    Official Full Name
    spleen associated tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:78063
    Locus tag
    EGK_07894
    See related
    Ensembl:ENSMMUG00000001748
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SYK in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (105792712..105921167)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (106927657..107023947)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114672677 Neighboring gene DIRAS family GTPase 2 Neighboring gene uncharacterized LOC106993834 Neighboring gene uncharacterized LOC106993835 Neighboring gene uncharacterized LOC114672844 Neighboring gene uncharacterized LOC114672845

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in macrophage activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neutrophil activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase SYK
    NP_001247964.1
    XP_014973556.1
    XP_014973557.1
    XP_014973558.1
    XP_028690116.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261035.1 → NP_001247964.1  tyrosine-protein kinase SYK

      See identical proteins and their annotated locations for NP_001247964.1

      Status: PROVISIONAL

      Source sequence(s)
      JV044044
      UniProtKB/TrEMBL
      A0A1D5QW34, A0A5F7ZUV3, A0A8J8Y2Y3, F7GLV6, G7NES2
      Related
      ENSMMUP00000052264.2, ENSMMUT00000077444.2
      Conserved Domains (3) summary
      cd05116
      Location:375 → 631
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:13 → 116
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:164 → 262
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      105792712..105921167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028834283.1 → XP_028690116.1  tyrosine-protein kinase SYK isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZUV3
      Conserved Domains (3) summary
      cd09938
      Location:13 → 116
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:164 → 262
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      cl21453
      Location:375 → 613
      PKc_like; Protein Kinases, catalytic domain

    2. XM_015118072.2 → XP_014973558.1  tyrosine-protein kinase SYK isoform X3

      UniProtKB/TrEMBL
      A0A5F7ZCV9, A0A5F7ZUV3
      Related
      ENSMMUP00000062441.1, ENSMMUT00000109455.1
      Conserved Domains (3) summary
      cd05116
      Location:352 → 608
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:13 → 116
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:164 → 262
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    3. XM_015118071.2 → XP_014973557.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A1D5QW34, A0A5F7ZUV3, A0A8J8Y2Y3, F7GLV6, G7NES2
      Related
      ENSMMUP00000063860.1, ENSMMUT00000083976.1
      Conserved Domains (3) summary
      cd05116
      Location:375 → 631
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:13 → 116
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:164 → 262
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    4. XM_015118070.2 → XP_014973556.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A1D5QW34, A0A5F7ZUV3, A0A8J8Y2Y3, F7GLV6, G7NES2
      Conserved Domains (3) summary
      cd05116
      Location:375 → 631
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:13 → 116
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:164 → 262
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
    Nucleotide Protein
    Heading Accession and Version

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