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    SMO smoothened, frizzled class receptor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701334, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SMOprovided by VGNC
    Official Full Name
    smoothened, frizzled class receptorprovided by VGNC
    Primary source
    VGNC:VGNC:77658
    See related
    Ensembl:ENSMMUG00000012110
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SMO in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (155439974..155465469)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (155237058..155263247)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene cytochrome c-like Neighboring gene tetraspanin 33 Neighboring gene adenosylhomocysteinase like 2 Neighboring gene uncharacterized LOC114677027 Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables patched binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in commissural neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    smoothened homolog
    Names
    smoothened, frizzled family receptor
    smoothened, seven transmembrane spanning receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      155439974..155465469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001093150.4 → XP_001093150.2  smoothened homolog isoform X2

      UniProtKB/TrEMBL
      F7H8W1, G7MMC2
      Related
      ENSMMUP00000015878.4, ENSMMUT00000016955.4
      Conserved Domains (2) summary
      cd07451
      Location:65 → 195
      CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
      cd15030
      Location:219 → 549
      7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

    2. XM_028846279.1 → XP_028702112.1  smoothened homolog isoform X1

      Conserved Domains (2) summary
      cd07451
      Location:65 → 195
      CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
      cd15030
      Location:219 → 549
      7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

    3. XM_028846283.1 → XP_028702116.1  smoothened homolog isoform X4

      Conserved Domains (2) summary
      cd07451
      Location:65 → 195
      CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
      cd15030
      Location:219 → 549
      7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors

    4. XM_028846282.1 → XP_028702115.1  smoothened homolog isoform X3

      Conserved Domains (2) summary
      cd15030
      Location:90 → 420
      7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
      cl02447
      Location:1 → 66
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

    5. XM_028846280.1 → XP_028702113.1  smoothened homolog isoform X3

      Conserved Domains (2) summary
      cd15030
      Location:90 → 420
      7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
      cl02447
      Location:1 → 66
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

    RNA

    1. XR_003728329.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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    Research Materials