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    KCNH8 potassium voltage-gated channel subfamily H member 8 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 697225, updated on 20-Oct-2024

    Summary

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    Official Symbol
    KCNH8provided by VGNC
    Official Full Name
    potassium voltage-gated channel subfamily H member 8provided by VGNC
    Primary source
    VGNC:VGNC:73855
    Locus tag
    EGK_12133
    See related
    Ensembl:ENSMMUG00000005370
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See KCNH8 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (28172299..28551511, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (178425643..178807703, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114676125 Neighboring gene uncharacterized LOC106997135 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106997133 Neighboring gene UV excision repair protein RAD23 homolog B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    voltage-gated delayed rectifier potassium channel KCNH8; potassium voltage-gated channel subfamily H member 8
    Names
    potassium voltage-gated channel, subfamily H (eag-related), member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261509.1 → NP_001248438.1  voltage-gated delayed rectifier potassium channel KCNH8

      See identical proteins and their annotated locations for NP_001248438.1

      Status: PROVISIONAL

      Source sequence(s)
      JU332942
      UniProtKB/TrEMBL
      A0A1D5QFS6, A0A8J8YAW9, G7MJX1
      Related
      ENSMMUP00000046896.2, ENSMMUT00000074964.2
      Conserved Domains (7) summary
      COG0664
      Location:548 → 685
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:551 → 662
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:42 → 133
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:239 → 481
      Ion_trans; Ion transport protein
      pfam06757
      Location:848 → 899
      Ins_allergen_rp; Insect allergen related repeat, nitrile-specifier detoxification
      pfam07885
      Location:421 → 475
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 135
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      28172299..28551511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015132243.2 → XP_014987729.1  potassium voltage-gated channel subfamily H member 8 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QFS6, A0A8J8YAW9, G7MJX1
      Conserved Domains (7) summary
      COG0664
      Location:548 → 685
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:551 → 662
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:42 → 133
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:239 → 481
      Ion_trans; Ion transport protein
      pfam06757
      Location:848 → 899
      Ins_allergen_rp; Insect allergen related repeat, nitrile-specifier detoxification
      pfam07885
      Location:421 → 475
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 135
      PAS_9; PAS domain
    Nucleotide Protein
    Heading Accession and Version

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