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    IBTK inhibitor of Bruton tyrosine kinase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 693559, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IBTKprovided by VGNC
    Official Full Name
    inhibitor of Bruton tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:73409
    See related
    Ensembl:ENSMMUG00000010749
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See IBTK in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (90845639..90925226)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (80363687..80443320, complement)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene trophoblast glycoprotein Neighboring gene single-stranded DNA-binding protein 2 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106998000 Neighboring gene uncharacterized LOC106997999

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibitor of Bruton tyrosine kinase
    Names
    inhibitor of Bruton agammaglobulinemia tyrosine kinase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      90845639..90925226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015136836.2 → XP_014992322.1  inhibitor of Bruton tyrosine kinase isoform X2

      UniProtKB/TrEMBL
      H9Z7G8
      Conserved Domains (8) summary
      smart00225
      Location:768 → 864
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5184
      Location:240 → 457
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00204
      Location:25 → 135
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14821
      Location:836 → 896
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00415
      Location:195 → 244
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam00651
      Location:553 → 641
      BTB; BTB/POZ domain
      pfam12796
      Location:25 → 116
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:51 → 82
      ANK; ANK repeat [structural motif]

    2. XM_015136835.2 → XP_014992321.1  inhibitor of Bruton tyrosine kinase isoform X1

      UniProtKB/TrEMBL
      F7FYD2, H9FSP2, H9Z7G8
      Related
      ENSMMUP00000014079.3, ENSMMUT00000015027.4
      Conserved Domains (8) summary
      smart00225
      Location:768 → 866
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5184
      Location:240 → 457
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00204
      Location:25 → 135
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14821
      Location:870 → 930
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00415
      Location:195 → 244
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam00651
      Location:760 → 866
      BTB; BTB/POZ domain
      pfam12796
      Location:25 → 116
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:51 → 82
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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