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    GCLC glutamate-cysteine ligase catalytic subunit [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 710508, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GCLCprovided by VGNC
    Official Full Name
    glutamate-cysteine ligase catalytic subunitprovided by VGNC
    Primary source
    VGNC:VGNC:72923
    Locus tag
    EGK_15023
    See related
    Ensembl:ENSMMUG00000008684
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See GCLC in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (116040781..116086499)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (54422987..54468462, complement)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene kelch like family member 31 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene uncharacterized LOC114677586 Neighboring gene homeobox protein NANOG pseudogene Neighboring gene WW domain-binding protein 11-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glutamate-cysteine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of glutamate-cysteine ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate--cysteine ligase catalytic subunit
    NP_001248036.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261107.1 → NP_001248036.1  glutamate--cysteine ligase catalytic subunit

      See identical proteins and their annotated locations for NP_001248036.1

      Status: PROVISIONAL

      Source sequence(s)
      JV044209
      UniProtKB/TrEMBL
      A0A1D5QEN7, A0A8J8Y0S5, F7EZ43, G7MPM0
      Related
      ENSMMUP00000046506.2, ENSMMUT00000058362.2
      Conserved Domains (2) summary
      PRK00087
      Location:22 → 76
      PRK00087; bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1
      pfam03074
      Location:236 → 608
      GCS; Glutamate-cysteine ligase

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      116040781..116086499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials