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    TYK2 tyrosine kinase 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574130, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TYK2provided by VGNC
    Official Full Name
    tyrosine kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:78680
    See related
    Ensembl:ENSMMUG00000003110
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TYK2 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (10110204..10144759, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (10382269..10418074, complement)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene ferredoxin 2 Neighboring gene ribonucleoprotein, PTB binding 1 Neighboring gene intercellular adhesion molecule 3 Neighboring gene cell division cycle 37, HSP90 cochaperone Neighboring gene phosphodiesterase 4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    non-receptor tyrosine-protein kinase TYK2
    XP_028695770.1
    XP_028695771.1
    XP_028695772.1
    XP_028695773.1
    XP_028695774.1
    XP_028695775.1
    XP_028695777.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      10110204..10144759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028839941.1 → XP_028695774.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZPU9, H9Z2G6
      Related
      ENSMMUP00000067206.1, ENSMMUT00000082366.1
      Conserved Domains (5) summary
      smart00295
      Location:28 → 273
      B41; Band 4.1 homologues
      cd05076
      Location:589 → 867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:892 → 1174
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:270 → 437
      PH-like; Pleckstrin homology-like domain

    2. XM_028839942.1 → XP_028695775.1  non-receptor tyrosine-protein kinase TYK2 isoform X3

      UniProtKB/TrEMBL
      A0A5F7ZDF4
      Related
      ENSMMUP00000063209.1, ENSMMUT00000105130.1
      Conserved Domains (4) summary
      smart00295
      Location:28 → 273
      B41; Band 4.1 homologues
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:270 → 437
      PH-like; Pleckstrin homology-like domain
      cl21453
      Location:589 → 867
      PKc_like; Protein Kinases, catalytic domain

    3. XM_028839937.1 → XP_028695770.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZPU9, F7DRD4, H9ZD33
      Conserved Domains (5) summary
      smart00295
      Location:28 → 273
      B41; Band 4.1 homologues
      cd05076
      Location:589 → 867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:895 → 1177
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:270 → 437
      PH-like; Pleckstrin homology-like domain

    4. XM_028839940.1 → XP_028695773.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZPU9, F7DRD4, H9ZD33
      Conserved Domains (5) summary
      smart00295
      Location:28 → 273
      B41; Band 4.1 homologues
      cd05076
      Location:589 → 867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:895 → 1177
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:270 → 437
      PH-like; Pleckstrin homology-like domain

    5. XM_028839938.1 → XP_028695771.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZPU9, F7DRD4, H9ZD33
      Conserved Domains (5) summary
      smart00295
      Location:28 → 273
      B41; Band 4.1 homologues
      cd05076
      Location:589 → 867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:895 → 1177
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:270 → 437
      PH-like; Pleckstrin homology-like domain

    6. XM_028839939.1 → XP_028695772.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZPU9, F7DRD4, H9ZD33
      Related
      ENSMMUP00000004150.4, ENSMMUT00000004400.4
      Conserved Domains (5) summary
      smart00295
      Location:28 → 273
      B41; Band 4.1 homologues
      cd05076
      Location:589 → 867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:895 → 1177
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:270 → 437
      PH-like; Pleckstrin homology-like domain

    7. XM_028839944.1 → XP_028695777.1  non-receptor tyrosine-protein kinase TYK2 isoform X4

      UniProtKB/TrEMBL
      A0A5F7ZPU9
      Conserved Domains (4) summary
      smart00295
      Location:28 → 273
      B41; Band 4.1 homologues
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:270 → 437
      PH-like; Pleckstrin homology-like domain
      cl21453
      Location:589 → 867
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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