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    CFB complement factor B [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 716809, updated on 5-Mar-2024

    Summary

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    Gene symbol
    CFB
    Gene description
    complement factor B
    See related
    Ensembl:ENSMMUG00000000729
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CFB in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (137543938..137549958, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (32833410..32839428)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 19 Neighboring gene decapping exoribonuclease Neighboring gene SKI2 subunit of superkiller complex Neighboring gene negative elongation factor complex member E Neighboring gene complement C2 Neighboring gene uncharacterized LOC114677635

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in complement activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    complement factor B
    Names
    complement factor B preproprotein
    XP_014991515.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      137543938..137549958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015136029.2 → XP_014991515.2  complement factor B

      UniProtKB/TrEMBL
      F6YJY7, G7MRL4, H9ZC51
      Related
      ENSMMUP00000000985.4, ENSMMUT00000001051.4
      Conserved Domains (4) summary
      cd00033
      Location:103 → 158
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:55 → 218
      PHA02927; secreted complement-binding protein; Provisional
      cd00190
      Location:488 → 754
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cd01470
      Location:269 → 465
      vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    Nucleotide Protein
    Heading Accession and Version

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