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    ROCK1 Rho associated coiled-coil containing protein kinase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 698223, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ROCK1provided by VGNC
    Official Full Name
    Rho associated coiled-coil containing protein kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:81559
    See related
    Ensembl:ENSMMUG00000004656
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ROCK1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 18 NC_041771.1 (61311019..61467663)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 18 NC_027910.1 (9397439..9554096, complement)

    Chromosome 18 - NC_041771.1Genomic Context describing neighboring genes Neighboring gene nuclease EXOG, mitochondrial pseudogene Neighboring gene uncharacterized LOC106994433 Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin specific peptidase 14 Neighboring gene THO complex subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in embryonic morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho-associated protein kinase 1
    NP_001248063.1
    XP_014977084.1
    XP_028693533.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261134.1 → NP_001248063.1  rho-associated protein kinase 1

      See identical proteins and their annotated locations for NP_001248063.1

      Status: PROVISIONAL

      Source sequence(s)
      JU476688
      UniProtKB/TrEMBL
      G7NKG1, H9EPT5
      Related
      ENSMMUP00000047862.1, ENSMMUT00000066869.2
      Conserved Domains (7) summary
      cd11639
      Location:489 → 554
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      smart00220
      Location:76 → 338
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0419
      Location:422 → 964
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:1229 → 1275
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1119 → 1225
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2 → 406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      pfam08912
      Location:949 → 1014
      Rho_Binding; Rho Binding

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041771.1 Reference Mmul_10 Primary Assembly

      Range
      61311019..61467663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028837700.1 → XP_028693533.1  rho-associated protein kinase 1 isoform X2

      UniProtKB/TrEMBL
      G7NKG1
      Conserved Domains (4) summary
      cd11639
      Location:489 → 554
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      COG0419
      Location:422 → 964
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd05622
      Location:2 → 406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      pfam08912
      Location:949 → 1014
      Rho_Binding; Rho Binding

    2. XM_015121598.2 → XP_014977084.1  rho-associated protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      G7NKG1
      Conserved Domains (7) summary
      cd11639
      Location:488 → 553
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      smart00220
      Location:76 → 338
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0419
      Location:412 → 963
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:1228 → 1274
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1118 → 1224
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2 → 406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      pfam08912
      Location:948 → 1013
      Rho_Binding; Rho Binding
    Nucleotide Protein
    Heading Accession and Version

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