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    TMPRSS2 transmembrane serine protease 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 715138, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TMPRSS2provided by VGNC
    Official Full Name
    transmembrane serine protease 2provided by VGNC
    Primary source
    VGNC:VGNC:78575
    See related
    Ensembl:ENSMMUG00000015332
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TMPRSS2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (5139757..5184755)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (5176312..5217342)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene small nucleolar RNA SNORA32 Neighboring gene MX dynamin like GTPase 1 Neighboring gene MX dynamin like GTPase 2 Neighboring gene uncharacterized LOC114676800

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acrosome reaction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protease serine 2
    Names
    transmembrane protease, serine 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      5139757..5184755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028845315.1 → XP_028701148.1  transmembrane protease serine 2 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZUD4
      Conserved Domains (3) summary
      cd00112
      Location:155 → 190
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:298 → 529
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:195 → 290
      SRCR_2; Scavenger receptor cysteine-rich domain

    2. XM_015132845.2 → XP_014988331.1  transmembrane protease serine 2 isoform X3

      UniProtKB/TrEMBL
      A0A1D5RIR7, F6SVR2, Q3I1U4
      Related
      ENSMMUP00000060211.1, ENSMMUT00000072841.2
      Conserved Domains (5) summary
      smart00020
      Location:255 → 484
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:113 → 148
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:256 → 487
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12868
      Location:7 → 54
      DUF3824; Domain of unknwon function (DUF3824)
      pfam15494
      Location:153 → 248
      SRCR_2; Scavenger receptor cysteine-rich domain

    3. XM_028845316.1 → XP_028701149.1  transmembrane protease serine 2 isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZUD4
      Related
      ENSMMUP00000068248.1, ENSMMUT00000093883.1
      Conserved Domains (3) summary
      cd00112
      Location:146 → 181
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:289 → 520
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:186 → 281
      SRCR_2; Scavenger receptor cysteine-rich domain
    Nucleotide Protein
    Heading Accession and Version

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