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    PDE8A phosphodiesterase 8A [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694750, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PDE8Aprovided by VGNC
    Official Full Name
    phosphodiesterase 8Aprovided by VGNC
    Primary source
    VGNC:VGNC:75924
    See related
    Ensembl:ENSMMUG00000019838
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PDE8A in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (63306860..63461590, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (63157084..63312082)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114679476 Neighboring gene MKI67 FHA domain-interacting nucleolar phosphoprotein pseudogene Neighboring gene uncharacterized LOC106999271 Neighboring gene uncharacterized LOC114679479 Neighboring gene nascent polypeptide-associated complex subunit alpha, muscle-specific form-like Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene solute carrier family 28 member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
    NP_001253573.1
    XP_014998391.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266644.1 → NP_001253573.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

      See identical proteins and their annotated locations for NP_001253573.1

      Status: PROVISIONAL

      Source sequence(s)
      JU322338
      UniProtKB/TrEMBL
      F7FU15, F7FU86
      Related
      ENSMMUP00000026089.2, ENSMMUT00000027886.4
      Conserved Domains (4) summary
      pfam08629
      Location:1 → 34
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:555 → 806
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:226 → 324
      PAS_9; PAS domain
      cl28069
      Location:121 → 346
      RocR; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      63306860..63461590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015142905.2 → XP_014998391.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

      UniProtKB/TrEMBL
      F7FU15
      Related
      ENSMMUP00000026090.3, ENSMMUT00000027887.4
      Conserved Domains (4) summary
      cd00130
      Location:236 → 330
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:561 → 813
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:1 → 34
      PDE8; PDE8 phosphodiesterase
      pfam13426
      Location:232 → 330
      PAS_9; PAS domain
    Nucleotide Protein
    Heading Accession and Version

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