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    HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 696008, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HACE1provided by VGNC
    Official Full Name
    HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1provided by VGNC
    Primary source
    VGNC:VGNC:73206
    See related
    Ensembl:ENSMMUG00000014703
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HACE1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (68349228..68476596)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (105389594..105524199)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene lin-28 homolog B Neighboring gene U6 spliceosomal RNA Neighboring gene translation initiation factor IF-2-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC114677391 Neighboring gene uncharacterized LOC106998055

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HACE1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      68349228..68476596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015137023.2 → XP_014992509.1  E3 ubiquitin-protein ligase HACE1 isoform X1

      UniProtKB/TrEMBL
      G7MPZ8
      Conserved Domains (6) summary
      smart00248
      Location:66 → 93
      ANK; ankyrin repeats
      cd00078
      Location:554 → 841
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:92 → 217
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:69 → 194
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199 → 249
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:97 → 128
      ANK; ANK repeat [structural motif]

    2. XM_015137024.1 → XP_014992510.1  E3 ubiquitin-protein ligase HACE1 isoform X2

      UniProtKB/TrEMBL
      G7MPZ8, H9EMB1
      Related
      ENSMMUP00000076059.1, ENSMMUT00000085869.1
      Conserved Domains (4) summary
      COG0666
      Location:83 → 220
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00078
      Location:554 → 903
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:97 → 128
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:34 → 126
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_028847311.1 → XP_028703144.1  E3 ubiquitin-protein ligase HACE1 isoform X6

      UniProtKB/TrEMBL
      A0A1D5QKV7, A0A5F8AGX3
      Related
      ENSMMUP00000048681.2, ENSMMUT00000057272.2
      Conserved Domains (4) summary
      cd00078
      Location:510 → 859
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:66 → 95
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:69 → 179
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:157 → 207
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_028847314.1 → XP_028703147.1  E3 ubiquitin-protein ligase HACE1 isoform X9

      UniProtKB/TrEMBL
      A0A5F8AGX3
      Conserved Domains (3) summary
      cd00078
      Location:392 → 741
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:1 → 32
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:6 → 89
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_015137027.2 → XP_014992513.1  E3 ubiquitin-protein ligase HACE1 isoform X4

      UniProtKB/TrEMBL
      A0A5F8AGX3
      Conserved Domains (6) summary
      smart00248
      Location:66 → 93
      ANK; ankyrin repeats
      cd00078
      Location:510 → 797
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:92 → 205
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:69 → 178
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:155 → 205
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:66 → 95
      ANK; ANK repeat [structural motif]

    6. XM_015137026.2 → XP_014992512.1  E3 ubiquitin-protein ligase HACE1 isoform X3

      UniProtKB/TrEMBL
      G7MPZ8
      Conserved Domains (4) summary
      cd00078
      Location:520 → 807
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:58 → 183
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:63 → 94
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:4 → 92
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_028847310.1 → XP_028703143.1  E3 ubiquitin-protein ligase HACE1 isoform X5

      UniProtKB/TrEMBL
      G7MPZ8
      Conserved Domains (4) summary
      COG0666
      Location:49 → 186
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00078
      Location:520 → 869
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:63 → 94
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:4 → 92
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_028847312.1 → XP_028703145.1  E3 ubiquitin-protein ligase HACE1 isoform X7

      UniProtKB/TrEMBL
      A0A5F8AGX3
      Conserved Domains (4) summary
      cd00078
      Location:476 → 825
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:32 → 61
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:35 → 145
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:123 → 173
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_028847313.1 → XP_028703146.1  E3 ubiquitin-protein ligase HACE1 isoform X8

      UniProtKB/TrEMBL
      A0A5F8AGX3
      Conserved Domains (3) summary
      cd00078
      Location:392 → 679
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:1 → 32
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:6 → 89
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_028847315.1 → XP_028703148.1  E3 ubiquitin-protein ligase HACE1 isoform X10

      Conserved Domains (4) summary
      PHA02878
      Location:15 → 182
      PHA02878; ankyrin repeat protein; Provisional
      cd00078
      Location:425 → 712
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:34 → 65
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:6 → 94
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_003728870.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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