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    SELENOS selenoprotein S [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694752, updated on 17-Aug-2024

    Summary

    Official Symbol
    SELENOSprovided by VGNC
    Official Full Name
    selenoprotein Sprovided by VGNC
    Primary source
    VGNC:VGNC:77344
    See related
    Ensembl:ENSMMUG00000053633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    SELS; VIMP
    Summary
    This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
    Orthologs
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    Genomic context

    See SELENOS in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (80556113..80562699, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (80033469..80038752, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat kinase 1 Neighboring gene uncharacterized LOC114679519 Neighboring gene chondroitin sulfate synthase 1 Neighboring gene uncharacterized LOC114679522 Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene uncharacterized LOC114679521

    Genomic regions, transcripts, and products

    General protein information

    Preferred Names
    selenoprotein S
    Names
    VCP interacting membrane selenoprotein
    VCP-interacting membrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114755.2NP_001108227.1  selenoprotein S isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes a selenocysteine-containing longer isoform (1).
      Source sequence(s)
      QNVO02000423
      UniProtKB/TrEMBL
      G7MWB7
      Conserved Domains (1) summary
      pfam06936
      Location:1188
      Selenoprotein_S; Selenoprotein S (SelS)
    2. NM_001348210.2NP_001335139.1  selenoprotein S isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1, and lacks a selenocysteine (Sec) insertion sequence (SECIS) element in its 3' UTR, which is necessary for the recognition of UGA as a Sec codon. This results in translation termination at the UGA codon and a non-Sec containing shorter isoform (2) compared to isoform 1 (PMID:23614019).
      Source sequence(s)
      QNVO02000423
      UniProtKB/TrEMBL
      F7H792, G7MWB7, I0FTC4
      Related
      ENSMMUP00000015512.4, ENSMMUT00000016561.4
      Conserved Domains (1) summary
      pfam06936
      Location:1188
      Selenoprotein_S; Selenoprotein S (SelS)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      80556113..80562699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)