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    KMT2A lysine methyltransferase 2A [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 705511, updated on 17-Aug-2024

    Summary

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    Official Symbol
    KMT2Aprovided by VGNC
    Official Full Name
    lysine methyltransferase 2Aprovided by VGNC
    Primary source
    VGNC:VGNC:101297
    See related
    Ensembl:ENSMMUG00000005482
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    MLL; all-1
    Orthologs
    human mouse all
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    Genomic context

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    See KMT2A in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (111496876..111593102)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (111277862..111371797)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene ubiquitination factor E4A Neighboring gene ATP synthase membrane subunit g Neighboring gene uncharacterized LOC114672416 Neighboring gene 60S ribosomal protein L6 pseudogene Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene transmembrane protein 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty. Toro CA, et al. Nat Commun, 2018 Jan 4. PMID 29302059, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MLL1 mRNA expression was increased in the medial basal hypothalamus.
      Title: Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone H3K4 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone methyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2A
    Names
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    XP_014971311.2
    XP_014971312.2
    XP_028689868.1
    XP_028689869.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      111496876..111593102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015115825.2 → XP_014971311.2  histone-lysine N-methyltransferase 2A isoform X2

      UniProtKB/TrEMBL
      G7NCC5
      Conserved Domains (9) summary
      cd05493
      Location:1649 → 1779
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3671 → 3754
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1432 → 1478
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1480 → 1529
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1567 → 1626
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1873 → 1985
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1146 → 1193
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3818 → 3971
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2026 → 2073
      FYRN; F/Y-rich N-terminus

    2. XM_015115826.2 → XP_014971312.2  histone-lysine N-methyltransferase 2A isoform X3

      UniProtKB/TrEMBL
      F7FZ57, G7NCC5
      Related
      ENSMMUP00000007251.4, ENSMMUT00000007721.4
      Conserved Domains (9) summary
      cd05493
      Location:1646 → 1776
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3668 → 3751
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1432 → 1478
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1480 → 1529
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1567 → 1623
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1870 → 1982
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1146 → 1193
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3815 → 3968
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2023 → 2070
      FYRN; F/Y-rich N-terminus

    3. XM_028834035.1 → XP_028689868.1  histone-lysine N-methyltransferase 2A isoform X1

      UniProtKB/TrEMBL
      F7FZ49, G7NCC5
      Related
      ENSMMUP00000007253.4, ENSMMUT00000007723.4
      Conserved Domains (9) summary
      cd05493
      Location:1679 → 1809
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3701 → 3784
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1465 → 1511
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1513 → 1562
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1600 → 1656
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1903 → 2015
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1179 → 1226
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3848 → 4001
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2056 → 2103
      FYRN; F/Y-rich N-terminus

    4. XM_028834036.1 → XP_028689869.1  histone-lysine N-methyltransferase 2A isoform X4

      Conserved Domains (10) summary
      cd05493
      Location:811 → 941
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:2833 → 2916
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:2995 → 3115
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:3117 → 3133
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam02008
      Location:308 → 355
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:594 → 640
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:642 → 691
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:729 → 788
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1035 → 1147
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:1188 → 1235
      FYRN; F/Y-rich N-terminus
    Nucleotide Protein
    Heading Accession and Version

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