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    HLCS holocarboxylase synthetase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694733, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HLCSprovided by VGNC
    Official Full Name
    holocarboxylase synthetaseprovided by VGNC
    Primary source
    VGNC:VGNC:73477
    See related
    Ensembl:ENSMMUG00000015566
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HLCS in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (9619302..9869009)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (9744256..9996223)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106997250 Neighboring gene microRNA mir-548i Neighboring gene ripply transcriptional repressor 3 Neighboring gene SIM bHLH transcription factor 2 Neighboring gene uncharacterized LOC114676813 Neighboring gene claudin 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables biotin--[biotin carboxyl-carrier protein] ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    biotin--protein ligase
    XP_001084173.2
    XP_014988396.1
    XP_014988397.1
    XP_014988398.1
    XP_014988399.1
    XP_028701161.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      9619302..9869009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015132912.2 → XP_014988398.1  biotin--protein ligase isoform X4

      UniProtKB/TrEMBL
      A0A1D5QH98, H9EWC5
      Related
      ENSMMUP00000069587.1, ENSMMUT00000107317.1
      Conserved Domains (3) summary
      cd16442
      Location:467 → 647
      BPL; biotin protein ligase
      pfam02237
      Location:669 → 716
      BPL_C; Biotin protein ligase C terminal domain
      cl00020
      Location:202 → 460
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

    2. XM_028845328.1 → XP_028701161.1  biotin--protein ligase isoform X4

      UniProtKB/TrEMBL
      A0A1D5QH98, H9EWC5
      Related
      ENSMMUP00000020423.3, ENSMMUT00000021835.4
      Conserved Domains (3) summary
      cd16442
      Location:467 → 647
      BPL; biotin protein ligase
      pfam02237
      Location:669 → 716
      BPL_C; Biotin protein ligase C terminal domain
      cl00020
      Location:202 → 460
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

    3. XM_001084173.4 → XP_001084173.2  biotin--protein ligase isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZY99, F6Q0T9
      Related
      ENSMMUP00000069620.1, ENSMMUT00000088057.1
      Conserved Domains (4) summary
      COG0340
      Location:642 → 864
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam02237
      Location:817 → 864
      BPL_C; Biotin protein ligase C terminal domain
      pfam03099
      Location:619 → 751
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family
      cl00020
      Location:350 → 608
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

    4. XM_015132910.2 → XP_014988396.1  biotin--protein ligase isoform X2

      UniProtKB/TrEMBL
      F6Q0T9
      Conserved Domains (2) summary
      pfam03099
      Location:619 → 748
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family
      cl00020
      Location:350 → 608
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

    5. XM_015132911.2 → XP_014988397.1  biotin--protein ligase isoform X3

      UniProtKB/TrEMBL
      F6Q0T9
      Conserved Domains (2) summary
      pfam03099
      Location:619 → 746
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family
      cl00020
      Location:350 → 608
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

    6. XM_015132913.2 → XP_014988399.1  biotin--protein ligase isoform X4

      UniProtKB/TrEMBL
      A0A1D5QH98, H9EWC5
      Conserved Domains (3) summary
      cd16442
      Location:467 → 647
      BPL; biotin protein ligase
      pfam02237
      Location:669 → 716
      BPL_C; Biotin protein ligase C terminal domain
      cl00020
      Location:202 → 460
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
    Nucleotide Protein
    Heading Accession and Version

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