DNMT1 DNA methyltransferase 1 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: DNMT1provided by VGNC
Official Full Name: DNA methyltransferase 1provided by VGNC
Primary source: VGNC:VGNC:71958
See related: Ensembl:ENSMMUG00000014604
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	19	NC_041772.1 (9879879..9942528, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	19	NC_027911.1 (10141560..10203690, complement)

Chromosome 19 - NC_041772.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH18124 (e-PCR)
- UniSTS:42581

D19S830 (e-PCR)
- UniSTS:32498

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA (cytosine-5-)-methyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DNA (cytosine-5)-methyltransferase 1

Names: DNA (cytosine-5-)-methyltransferase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041772.1 Reference Mmul_10 Primary Assembly

Range

9879879..9942528 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015122836.2 → XP_014978322.2 DNA (cytosine-5)-methyltransferase 1 isoform X5

UniProtKB/TrEMBL

F7GPW3

Related

ENSMMUP00000019170.4, ENSMMUT00000020484.4

Conserved Domains (7) summary

COG0270
Location:1201 → 1655

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd04711
Location:1028 → 1164

BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

cd04760
Location:817 → 940

BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

pfam02008
Location:708 → 754

zf-CXXC; CXXC zinc finger domain

pfam06464
Location:79 → 168

DMAP_binding; DMAP1-binding Domain

pfam10243
Location:182 → 414

MIP-T3; Microtubule-binding protein MIP-T3

pfam12047
Location:465 → 595

DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
XM_015122835.2 → XP_014978321.2 DNA (cytosine-5)-methyltransferase 1 isoform X4

UniProtKB/TrEMBL

H9Z5Z3

Conserved Domains (7) summary

COG0270
Location:1138 → 1595

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd04711
Location:965 → 1101

BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

cd04760
Location:754 → 877

BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

pfam02008
Location:645 → 691

zf-CXXC; CXXC zinc finger domain

pfam06464
Location:16 → 105

DMAP_binding; DMAP1-binding Domain

pfam10243
Location:119 → 351

MIP-T3; Microtubule-binding protein MIP-T3

pfam12047
Location:402 → 532

DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
XM_015122838.2 → XP_014978324.2 DNA (cytosine-5)-methyltransferase 1 isoform X6

UniProtKB/TrEMBL

H9Z5Z3

Related

ENSMMUP00000060915.2, ENSMMUT00000060219.2

Conserved Domains (6) summary

COG0270
Location:1104 → 1561

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd04711
Location:931 → 1067

BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

cd04760
Location:720 → 843

BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

pfam02008
Location:611 → 657

zf-CXXC; CXXC zinc finger domain

pfam06464
Location:16 → 105

DMAP_binding; DMAP1-binding Domain

pfam12047
Location:368 → 498

DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
XM_028839276.1 → XP_028695109.1 DNA (cytosine-5)-methyltransferase 1 isoform X3

UniProtKB/TrEMBL

H9Z5Z3

Conserved Domains (7) summary

COG0270
Location:1244 → 1701

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd04711
Location:1071 → 1207

BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

cd04760
Location:860 → 983

BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

pfam02008
Location:751 → 797

zf-CXXC; CXXC zinc finger domain

pfam06464
Location:168 → 245

DMAP_binding; DMAP1-binding Domain

pfam10243
Location:243 → 457

MIP-T3; Microtubule-binding protein MIP-T3

pfam12047
Location:508 → 638

DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
XM_015122837.2 → XP_014978323.2 DNA (cytosine-5)-methyltransferase 1 isoform X1

UniProtKB/TrEMBL

H9Z5Z3

Conserved Domains (6) summary

COG0270
Location:1017 → 1474

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd04711
Location:844 → 980

BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

cd04760
Location:633 → 756

BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

pfam02008
Location:524 → 570

zf-CXXC; CXXC zinc finger domain

pfam10243
Location:4 → 230

MIP-T3; Microtubule-binding protein MIP-T3

pfam12047
Location:281 → 411

DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
XM_028839275.1 → XP_028695108.1 DNA (cytosine-5)-methyltransferase 1 isoform X2

UniProtKB/TrEMBL

H9YV74

Conserved Domains (6) summary

COG0270
Location:1017 → 1471

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd04711
Location:844 → 980

BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

cd04760
Location:633 → 756

BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

pfam02008
Location:524 → 570

zf-CXXC; CXXC zinc finger domain

pfam10243
Location:4 → 230

MIP-T3; Microtubule-binding protein MIP-T3

pfam12047
Location:281 → 411

DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
XM_028839277.1 → XP_028695110.1 DNA (cytosine-5)-methyltransferase 1 isoform X1

UniProtKB/TrEMBL

H9Z5Z3

Conserved Domains (6) summary

COG0270
Location:1017 → 1474

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd04711
Location:844 → 980

BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

cd04760
Location:633 → 756

BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

pfam02008
Location:524 → 570

zf-CXXC; CXXC zinc finger domain

pfam10243
Location:4 → 230

MIP-T3; Microtubule-binding protein MIP-T3

pfam12047
Location:281 → 411

DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
XM_015122839.2 → XP_014978325.2 DNA (cytosine-5)-methyltransferase 1 isoform X1

UniProtKB/TrEMBL

H9Z5Z3

Conserved Domains (6) summary

COG0270
Location:1017 → 1474

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd04711
Location:844 → 980

BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

cd04760
Location:633 → 756

BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

pfam02008
Location:524 → 570

zf-CXXC; CXXC zinc finger domain

pfam10243
Location:4 → 230

MIP-T3; Microtubule-binding protein MIP-T3

pfam12047
Location:281 → 411

DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
XM_028839278.1 → XP_028695111.1 DNA (cytosine-5)-methyltransferase 1 isoform X7

Conserved Domains (5) summary

COG0270
Location:802 → 1259

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd04711
Location:629 → 765

BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

cd04760
Location:418 → 541

BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...

pfam02008
Location:309 → 355

zf-CXXC; CXXC zinc finger domain

pfam12047
Location:66 → 196

DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain