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    IL1RN interleukin 1 receptor antagonist [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701658, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IL1RNprovided by VGNC
    Official Full Name
    interleukin 1 receptor antagonistprovided by VGNC
    Primary source
    VGNC:VGNC:73723
    See related
    Ensembl:ENSMMUG00000013014
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See IL1RN in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (16298692..16314460)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 13 NC_027905.1 (108115924..108131728)

    Chromosome 13 - NC_041766.1Genomic Context describing neighboring genes Neighboring gene interleukin 1 family member 10 Neighboring gene U6 spliceosomal RNA Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene paired box 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Rafiq S, et al. Genes Immun, 2007 Jun. PMID 17443229
    2. Association between the interleukin-1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment. Mata I, et al. Am J Med Genet B Neuropsychiatr Genet, 2006 Dec 5. PMID 16921503
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The variable number of tandem repeats polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs.
      Title: Association between the interleukin-1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment.
    2. common variation across the IL-1RN gene is strongly associated with IL-1RA levels.
      Title: Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables interleukin-1 receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables interleukin-1 receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-1 receptor antagonist protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041766.1 Reference Mmul_10 Primary Assembly

      Range
      16298692..16314460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015113137.2 → XP_014968623.1  interleukin-1 receptor antagonist protein isoform X2

      UniProtKB/TrEMBL
      F7HP64
      Related
      ENSMMUP00000017085.4, ENSMMUT00000018251.4
      Conserved Domains (1) summary
      smart00125
      Location:16 → 156
      IL1; Interleukin-1 homologues

    2. XM_015113138.2 → XP_014968624.1  interleukin-1 receptor antagonist protein isoform X3

      Conserved Domains (1) summary
      smart00125
      Location:1 → 140
      IL1; Interleukin-1 homologues

    3. XM_001091833.4 → XP_001091833.1  interleukin-1 receptor antagonist protein isoform X1

      See identical proteins and their annotated locations for XP_001091833.1

      UniProtKB/TrEMBL
      A0A1D5Q1Y0, F7HP64
      Related
      ENSMMUP00000042042.2, ENSMMUT00000067411.2
      Conserved Domains (1) summary
      smart00125
      Location:34 → 174
      IL1; Interleukin-1 homologues
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases
    Research Materials