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    ARHGEF28 Rho guanine nucleotide exchange factor 28 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 703897, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ARHGEF28provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 28provided by VGNC
    Primary source
    VGNC:VGNC:84279
    See related
    Ensembl:ENSMMUG00000017897
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    RGNEF
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF28 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (70543215..70794480)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (70322927..70574670)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat family A member 2 Neighboring gene UTP15 small subunit processome component Neighboring gene ATP synthase-coupling factor 6, mitochondrial-like Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC106998798 Neighboring gene uncharacterized LOC114678688

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 28
    Names
    190 kDa guanine nucleotide exchange factor
    Rho guanine nucleotide exchange factor (GEF) 28
    Rho-guanine nucleotide exchange factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      70543215..70794480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028849510.1 → XP_028705343.1  rho guanine nucleotide exchange factor 28 isoform X4

      UniProtKB/TrEMBL
      G7MUQ8
      Conserved Domains (3) summary
      smart00325
      Location:851 → 1040
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:653 → 697
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14680
      Location:1085 → 1185
      PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

    2. XM_015140272.2 → XP_014995758.2  rho guanine nucleotide exchange factor 28 isoform X1

      UniProtKB/TrEMBL
      F7F1G4, G7MUQ8
      Related
      ENSMMUP00000023527.4, ENSMMUT00000025148.4
      Conserved Domains (3) summary
      smart00325
      Location:851 → 1040
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:653 → 697
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14680
      Location:1085 → 1185
      PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

    3. XM_028849507.1 → XP_028705340.1  rho guanine nucleotide exchange factor 28 isoform X2

      UniProtKB/TrEMBL
      F7F119, G7MUQ8
      Related
      ENSMMUP00000023532.4, ENSMMUT00000025154.4
      Conserved Domains (3) summary
      smart00325
      Location:753 → 942
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:555 → 599
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl17171
      Location:987 → 1087
      PH-like; Pleckstrin homology-like domain

    4. XM_028849509.1 → XP_028705342.1  rho guanine nucleotide exchange factor 28 isoform X3

      Conserved Domains (3) summary
      smart00325
      Location:538 → 727
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:340 → 384
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14680
      Location:772 → 872
      PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    Nucleotide Protein
    Heading Accession and Version

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