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    DOT1L DOT1 like histone lysine methyltransferase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 710033, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DOT1Lprovided by VGNC
    Official Full Name
    DOT1 like histone lysine methyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:71901
    See related
    Ensembl:ENSMMUG00000010107
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See DOT1L in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (2006030..2078377)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (2041857..2117058)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene IZUMO family member 4 Neighboring gene adaptor related protein complex 3 subunit delta 1 Neighboring gene pleckstrin homology domain containing J1 Neighboring gene microRNA mir-1227 Neighboring gene splicing factor 3a subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone H3K79 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase, H3 lysine-79 specific
    Names
    DOT1-like, histone H3 methyltransferase
    XP_014977895.1
    XP_014977897.1
    XP_028694505.1
    XP_028694507.1
    XP_028694508.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      2006030..2078377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015122411.2 → XP_014977897.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X5

      UniProtKB/TrEMBL
      F6R766, F6R779, H9G0R7
      Related
      ENSMMUP00000013214.4, ENSMMUT00000014110.4
      Conserved Domains (3) summary
      pfam08123
      Location:115 → 317
      DOT1; Histone methylation protein DOT1
      pfam12718
      Location:508 → 660
      Tropomyosin_1; Tropomyosin like
      pfam15035
      Location:493 → 661
      Rootletin; Ciliary rootlet component, centrosome cohesion

    2. XM_015122409.2 → XP_014977895.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2

      UniProtKB/TrEMBL
      A0A5F8AS85, F6R779
      Related
      ENSMMUP00000080815.1, ENSMMUT00000105834.1
      Conserved Domains (3) summary
      pfam08123
      Location:115 → 317
      DOT1; Histone methylation protein DOT1
      pfam12718
      Location:508 → 660
      Tropomyosin_1; Tropomyosin like
      pfam15035
      Location:493 → 661
      Rootletin; Ciliary rootlet component, centrosome cohesion

    3. XM_028838674.1 → XP_028694507.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3

      UniProtKB/TrEMBL
      F6R779
      Conserved Domains (4) summary
      pfam08123
      Location:61 → 263
      DOT1; Histone methylation protein DOT1
      PHA03247
      Location:830 → 1312
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:729 → 1070
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam17380
      Location:244 → 601
      DUF5401; Family of unknown function (DUF5401)

    4. XM_028838672.1 → XP_028694505.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1

      UniProtKB/TrEMBL
      A0A1D5QRE5, F6R779
      Related
      ENSMMUP00000050623.2, ENSMMUT00000053694.2
      Conserved Domains (4) summary
      pfam08123
      Location:157 → 359
      DOT1; Histone methylation protein DOT1
      PHA03247
      Location:926 → 1408
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:825 → 1166
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam17380
      Location:340 → 697
      DUF5401; Family of unknown function (DUF5401)

    5. XM_028838675.1 → XP_028694508.1  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X4

      UniProtKB/TrEMBL
      A0A5K1UQN6, F6R779
      Related
      ENSMMUP00000013215.4, ENSMMUT00000014111.4
      Conserved Domains (4) summary
      pfam08123
      Location:157 → 359
      DOT1; Histone methylation protein DOT1
      PHA03247
      Location:926 → 1408
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:825 → 1166
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam17380
      Location:340 → 697
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein
    Heading Accession and Version

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