TNK2 tyrosine kinase non receptor 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: TNK2provided by VGNC
Official Full Name: tyrosine kinase non receptor 2provided by VGNC
Primary source: VGNC:VGNC:79192
See related: Ensembl:ENSMMUG00000000972
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	2	NC_041755.1 (687706..734693, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	2	NC_027894.1 (202560836..202609328, complement)

Chromosome 2 - NC_041755.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

ksks337 (e-PCR)
- UniSTS:514383

STS-R44803 (e-PCR)
- UniSTS:10961

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of keratinocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: activated CDC42 kinase 1

XP_001101686.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_014988041.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_014988043.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_014988044.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_014988048.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_014988053.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_028699354.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_028699355.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_028699356.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_028699357.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_028699358.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_028699359.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_028699360.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

XP_028699361.1

EC 2.7.10.1

EC 2.7.10.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041755.1 Reference Mmul_10 Primary Assembly

Range

687706..734693 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001101686.4 → XP_001101686.1 activated CDC42 kinase 1 isoform X13

See identical proteins and their annotated locations for XP_001101686.1

UniProtKB/TrEMBL

H9FNI3

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:577 → 953

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:958 → 1002

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:989 → 1028

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:774 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
XM_015132562.2 → XP_014988048.1 activated CDC42 kinase 1 isoform X11

UniProtKB/TrEMBL

H9FNI3

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:615 → 991

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:999 → 1042

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1029 → 1068

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain

pfam09027
Location:447 → 514

GTPase_binding; GTPase binding

pfam11555
Location:812 → 876

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
XM_028843528.1 → XP_028699361.1 activated CDC42 kinase 1 isoform X11

UniProtKB/TrEMBL

H9FNI3

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:615 → 991

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:999 → 1042

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1029 → 1068

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain

pfam09027
Location:447 → 514

GTPase_binding; GTPase binding

pfam11555
Location:812 → 876

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
XM_028843525.1 → XP_028699358.1 activated CDC42 kinase 1 isoform X6

UniProtKB/TrEMBL

H9FNI3

Related

ENSMMUP00000067964.1, ENSMMUT00000096154.1

Conserved Domains (8) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:601 → 977

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:985 → 1028

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1015 → 1054

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain

pfam09027
Location:471 → 538

GTPase_binding; GTPase binding

pfam11555
Location:798 → 862

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
XM_028843523.1 → XP_028699356.1 activated CDC42 kinase 1 isoform X4

UniProtKB/TrEMBL

H9FNI3

Related

ENSMMUP00000038203.3, ENSMMUT00000045187.3

Conserved Domains (8) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:616 → 992

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:1000 → 1043

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1030 → 1069

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain

pfam09027
Location:471 → 538

GTPase_binding; GTPase binding

pfam11555
Location:813 → 877

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
XM_028843524.1 → XP_028699357.1 activated CDC42 kinase 1 isoform X5

UniProtKB/TrEMBL

H9FNI3

Conserved Domains (7) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:639 → 1015

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:1021 → 1060

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain

pfam09027
Location:471 → 538

GTPase_binding; GTPase binding

pfam11555
Location:836 → 900

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
XM_028843521.1 → XP_028699354.1 activated CDC42 kinase 1 isoform X2

UniProtKB/TrEMBL

H9FNI3

Conserved Domains (8) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:639 → 1015

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:1020 → 1064

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1051 → 1090

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain

pfam09027
Location:471 → 538

GTPase_binding; GTPase binding

pfam11555
Location:836 → 900

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
XM_015132558.2 → XP_014988044.1 activated CDC42 kinase 1 isoform X1

UniProtKB/TrEMBL

H9FNI3

Conserved Domains (8) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

cd14274
Location:1023 → 1066

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1053 → 1092

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain

pfam09027
Location:471 → 538

GTPase_binding; GTPase binding

pfam11555
Location:836 → 900

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

cl26464
Location:639 → 1015

Atrophin-1; Atrophin-1 family
XM_028843522.1 → XP_028699355.1 activated CDC42 kinase 1 isoform X3

UniProtKB/TrEMBL

H9FNI3

Conserved Domains (8) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:622 → 998

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:1006 → 1049

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1036 → 1075

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:137 → 394

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam14604
Location:402 → 451

SH3_9; Variant SH3 domain

pfam09027
Location:454 → 521

GTPase_binding; GTPase binding

pfam11555
Location:819 → 883

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
XM_015132567.2 → XP_014988053.1 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

H9FNI3

Related

ENSMMUP00000068836.1, ENSMMUT00000099184.1

Conserved Domains (7) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

smart00221
Location:158 → 417

STYKc; Protein kinase; unclassified specificity

cd14328
Location:991 → 1030

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:479 → 546

GTPase_binding; GTPase binding

pfam11555
Location:806 → 870

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain
XM_015132557.2 → XP_014988043.1 activated CDC42 kinase 1 isoform X10

UniProtKB/TrEMBL

H9FNI3

Related

ENSMMUP00000038201.3, ENSMMUT00000045185.3

Conserved Domains (8) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

smart00221
Location:158 → 417

STYKc; Protein kinase; unclassified specificity

cd14274
Location:1031 → 1074

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1061 → 1100

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:479 → 546

GTPase_binding; GTPase binding

pfam11555
Location:844 → 908

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain
XM_015132555.2 → XP_014988041.1 activated CDC42 kinase 1 isoform X9

UniProtKB/TrEMBL

F6SXS7

Related

ENSMMUP00000001308.4, ENSMMUT00000001390.4

Conserved Domains (8) summary

cd09539
Location:43 → 104

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

cd14274
Location:1036 → 1079

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1066 → 1105

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:167 → 424

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam14604
Location:432 → 481

SH3_9; Variant SH3 domain

pfam09027
Location:484 → 551

GTPase_binding; GTPase binding

pfam11555
Location:849 → 913

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

cl26464
Location:652 → 1028

Atrophin-1; Atrophin-1 family
XM_028843527.1 → XP_028699360.1 activated CDC42 kinase 1 isoform X8

UniProtKB/TrEMBL

H9FNI3

Conserved Domains (7) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:601 → 977

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:983 → 1022

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain

pfam09027
Location:471 → 538

GTPase_binding; GTPase binding

pfam11555
Location:798 → 862

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
XM_028843526.1 → XP_028699359.1 activated CDC42 kinase 1 isoform X7

UniProtKB/TrEMBL

H9FNI3

Conserved Domains (8) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:601 → 977

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:982 → 1026

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1013 → 1052

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain

pfam09027
Location:471 → 538

GTPase_binding; GTPase binding

pfam11555
Location:798 → 862

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6