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    FGD4 FYVE, RhoGEF and PH domain containing 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 695281, updated on 17-Aug-2024

    Summary

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    Official Symbol
    FGD4provided by VGNC
    Official Full Name
    FYVE, RhoGEF and PH domain containing 4provided by VGNC
    Primary source
    VGNC:VGNC:72534
    See related
    Ensembl:ENSMMUG00000004851
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See FGD4 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (33532387..33797009)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (33457489..33723134)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene retroelement silencing factor 1 Neighboring gene BICD cargo adaptor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC114670822 Neighboring gene dynamin 1 like Neighboring gene nucleosome assembly protein 1-like 1 pseudogene Neighboring gene tyrosyl-tRNA synthetase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FYVE, RhoGEF and PH domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      33532387..33797009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001084734.3 → XP_001084734.3  FYVE, RhoGEF and PH domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A1D5R445, F6Y202
      Related
      ENSMMUP00000055081.2, ENSMMUT00000062204.2
      Conserved Domains (4) summary
      cd00160
      Location:372 → 556
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:802 → 904
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:588 → 681
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:719 → 783
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4

    2. XM_015151412.2 → XP_015006898.2  FYVE, RhoGEF and PH domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A5F7ZLK5, F6Y202
      Related
      ENSMMUP00000066512.1, ENSMMUT00000098275.1
      Conserved Domains (4) summary
      cd00160
      Location:293 → 477
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:723 → 825
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:509 → 602
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:640 → 704
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4

    3. XM_028829400.1 → XP_028685233.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X4

      UniProtKB/TrEMBL
      A0A5S6RB65, A0A8J8Y1B5, F6Y202, F7AWU7, G7N6N9
      Conserved Domains (4) summary
      cd00160
      Location:207 → 391
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:637 → 739
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:423 → 516
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:554 → 618
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4

    4. XM_028829402.1 → XP_028685235.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X6

      Conserved Domains (4) summary
      cd00160
      Location:23 → 207
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:453 → 555
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:239 → 332
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:370 → 434
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4

    5. XM_028829399.1 → XP_028685232.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X4

      UniProtKB/TrEMBL
      A0A5S6RB65, A0A8J8Y1B5, F6Y202, F7AWU7, G7N6N9
      Related
      ENSMMUP00000006449.4, ENSMMUT00000006856.4
      Conserved Domains (4) summary
      cd00160
      Location:207 → 391
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:637 → 739
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:423 → 516
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:554 → 618
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4

    6. XM_015151411.2 → XP_015006897.2  FYVE, RhoGEF and PH domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      F6Y202, F6Y210
      Related
      ENSMMUP00000040003.3, ENSMMUT00000046972.3
      Conserved Domains (4) summary
      cd00160
      Location:320 → 504
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:750 → 852
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:536 → 629
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:667 → 731
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4

    7. XM_028829401.1 → XP_028685234.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X5

      Conserved Domains (4) summary
      cd00160
      Location:114 → 298
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:544 → 646
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:330 → 423
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:461 → 525
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4

    8. XM_015151413.2 → XP_015006899.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X7

      Conserved Domains (5) summary
      cd13236
      Location:389 → 491
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:175 → 268
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:306 → 370
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:175 → 272
      PH; PH domain
      pfam00621
      Location:2 → 143
      RhoGEF; RhoGEF domain
    Nucleotide Protein
    Heading Accession and Version

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